TPCK | Serine protease inhibitor

CAS:
402-71-1
Catalog Number:
10-2290
Activity:
Serine protease inhibitor
Chemical Name:
N-p-Tosyl-L-phenylalanine chloromethyl ketone
Molecular Weight:
351.8
Molecular Formula:
C17H18ClNO3S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
100 mg$32.00
500 mg$100.00
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TPCK (402-71-1) is an irreversible inhibitor of the serine protease chymotrypsin.1 It also inhibits certain cysteine proteases (bromelain, ficin, papain).1 TPCK inhibited (IC50 = 5 μM) the mitogen-induced activation of pp70s6k, a mitogen-regulated serine/threonine kinase involved in the G1 to S phase transition of the cell cycle.2

References/Citations:

1) Bond and Butler, (1987) Intracellular proteases; Annu. Rev. Biochem., 56 333
2) Grammer and Blenis (1996) The serine protease inhibitors, tosylphenylalanine chloromethylketone and tosyllysine chloromethylketone, potently inhibit pp70s6k activation; J. Biol. Chem., 271 23650

CAS:
402-71-1
Catalog Number:
10-2290
Activity:
Serine protease inhibitor
Chemical Name:
N-p-Tosyl-L-phenylalanine chloromethyl ketone
Molecular Weight:
351.8
Molecular Formula:
C17H18ClNO3S
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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