TPPU | Soluble epoxide hydrolase inhibitor

TPPU (1222780-33-7) is a potent and selective inhibitor of both murine and human soluble epoxide hydrolase, IC₅₀=2.8 and 3.7 nM respectively.¹ It alleviated blood brain barrier damage and attenuated neuronal injury in a mouse intracerebral hemorrhage model² and displays neuroprotective effects in ischemic injury³. It reduces neuroinflammation in a mouse model of Alzheimer’s disease.⁴ It improves insulin resistance and reduced hypertension in mouse models.⁵ Cell permeable and active in vivo.

References/Citations:

1. Rose et al. (2010), 1-Aryl-3-(1-acylpiperidin-4-yl)urea inhibitors of human and murine soluble epoxide hydrolase: structure-activity relationships, pharmacokinetics, and reduction of inflammatory pain; J. Med. Chem. 53 7067
2. Tian et al. (2021), Soluble epoxide hydrolase inhibitor attenuates BBB disruption and neuroinflammation after intracerebral hemorrhage in mice; Neurochem. Int. 150 105197
3. Yi et al. (2021), 1-Trifluoromethoxyphenyl-3-(1-propionylpiperidin-4-yl) Urea Exerts Neuro-Protective Effects Against Ischemic Injury via Suppressing JNK/p38 MAPK-Mediated Mitochondrial Apoptosis Pathway; J. Stroke Cerebrovasc. Dis. 30 105957
4. Ghosh et al. (2020), An epoxide hydrolase inhibitor reduces neuroinflammation in a mouse model of Alzheimer’s disease; Sci. Transl. Med. 12 eabb1206
5. Luo et al. (2021), Inhibition of soluble epoxide hydrolase alleviates insulin resistance and hypertension via downregulation of SGLT2 in the mouse kidney; J. Biol. Chem. 296 100667