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Product Details

(±) Tranylcypromine hemisulfate | Demethylase inhibitor

Tranylcypromine (13492-01-8) is an irreversible and non-selective monoamine oxidase inhibitor.1,2 It has been shown to inhibit the histone demethylase BHC110/LSD1.3,4

References/Citations
1) Knoll et al. (1980), Monoamine oxidase inhibitors: Chemistry and Pharmacology; In, Sandler (ed) Enzyme inhibtors as drugs, MacMillan, London 151
2) Baker et al. (1992), Insights into the mechanisms of action of the MAO inhibitors phenelzine and tranylcypromine; a review, J.Psychiatry Neurosci. 17 206
3) Lee et al. (2006), Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications; Chemistry and Biology, 13 563
4) Schmidt and McCafferty (2007), trans-2-Phenylcyclopropylamine is a Mechanism-Based Inactivator of the Histone Demethylase LSD1; Biochemistry, 46 4408

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Catalog#  10-4535

$40.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
13492-01-8
Catalog Number:
10-4535
Activity:
Demethylase inhibitor
Chemical Name:
trans-(±)-2-Phenylcyclopropylamine hemisulfate
Molecular Weight:
182.23
Molecular Formula:
C9H11N 1/2(H2SO4)
Solubility:
Soluble in Water (up to 25 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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