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Tryptanthrin | Immunomodulator; IDO2 inhibitor

Tryptanthrin (13220-57-0) is an indoloquinazoline alkaloid found in various plant species and possessing intriguing pharmacological activities.1Suppresses activation of BV2 microglia cells following LPS treatment and reduces production of proinflammatory cytokines via Nrf2, HO-1 and NFκB signaling.2  Displays antiinflammatory activity targeting IL-17.3 Inhibits indoleamine 2,3-dioxygenase 2 (IDO2) with an IC50 of 5-17 mM.4 Induces growth inhibition and neuronal differentiation in human neuroblastoma LA-N-1 cells.5

References/Citations

1) Jahng et al. (2013), Progress in the studies on tryptanthrin, an alkaloid of history; Arch. Pharm. Res., 36 517
2) Kwon et al. (2017), Tryptanthrin Supresses the Activation of the LPS-Treated BV2 Microglial Cell Line via Nrf2/HO-1 Antioxidant Signaling; Front. Cell. Neurosci., 11 18
3) Cheng et al. (2017), Clinical efficacy and IL-17 targeting mechanism of Indigo naturalis as a topical agent in moderate psoriasis; BMC Complement. Altern. Med., 17 439
4) Li et al. (2016), Establishment of a human indoleamine 2,3-dioxygenase 2 (hIDO2) bioassay system and discovery of tryptanthrin derivatives as potent hIDO2 inhibitors; Eur. J. Med. Chem., 123 171
5) Liao and Leung (2013), Tryptanthrin induces growth inhibition and neuronal differentiation in the human neuroblastoma LA-N-1 cells; Eur. Chem. Biol. Interact., 203 512

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Tryptanthrin | Immunomodulator | CAS 13220-57-0

Catalog#  10-2228

$50.00
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CAS:
13220-57-0
Catalog Number:
10-2228
Activity:
Immunomodulator; IDO2 inhibitor
Chemical Name:
Indolo(2,1-b)quinazoline-6,12-dione
Alternate Names:
NSC 349447; Couroupitine A
Molecular Weight:
248.24
Molecular Formula:
C15H8N2O2
Solubility:
Soluble in DMSO (up to 30 mg/ml)
Physical Properties:
Yellow solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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