TTK21 | CBP/p300 histone acetyltransferase activator
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $65.00 | ||
| 25 mg | $240.00 |
TTK21 (709676-56-2) is a novel activator of CBP/p300 acetyl transferases.1 When TTK21 is conjugated to glucose-based carbon nanospheres (CSP) it is nontoxic and is BBB permeable. CSP-TTK21, upon intraperitoneal administration to mice, acetylated histones in the hippocampus and frontal cortex and increased BDNF levels.1 It reinstated plasticity and memory in a tauopathy mouse model2, ameliorated Aβ-impaired long term potentiation3 and promoted axon growth, sprouting and synaptic plasticity in chronic experimental spinal cord injury4.
References/Citations:
- Chatterjee et al. (2013) A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice; J. Neurosci. 33 10698
- Chatterjee et al. (2018) Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator; EMBO Mol. Med. 103 e8587
- Singh et al. (2022) Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons; Aging Cell 21 e13675
- Muller et al. (2022) CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disability; PLoS Biol. 20 e3001310
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
TTK21 (709676-56-2) is a novel activator of CBP/p300 acetyl transferases.1 When TTK21 is conjugated to glucose-based carbon nanospheres (CSP) it is nontoxic and is BBB permeable. CSP-TTK21, upon intraperitoneal administration to mice, acetylated histones in the hippocampus and frontal cortex and increased BDNF levels.1 It reinstated plasticity and memory in a tauopathy mouse model2, ameliorated Aβ-impaired long term potentiation3 and promoted axon growth, sprouting and synaptic plasticity in chronic experimental spinal cord injury4.
References/Citations:
- Chatterjee et al. (2013) A novel activator of CBP/p300 acetyltransferases promotes neurogenesis and extends memory duration in adult mice; J. Neurosci. 33 10698
- Chatterjee et al. (2018) Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator; EMBO Mol. Med. 103 e8587
- Singh et al. (2022) Glucose derived carbon nanosphere (CSP) conjugated TTK21, an activator of the histone acetyltransferases CBP/p300, ameliorates amyloid-beta 1-42 induced deficits in plasticity and associativity in hippocampal CA1 pyramidal neurons; Aging Cell 21 e13675
- Muller et al. (2022) CBP/p300 activation promotes axon growth, sprouting, and synaptic plasticity in chronic experimental spinal cord injury with severe disability; PLoS Biol. 20 e3001310
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