my account
Login
  Loading... Please wait...

Product Details

TUDCA | ER stress inhibitor

TUDCA (14605-22-2) is a classic inhibitor of endoplasmic reticulum (ER) stress.1 Reduces ER stress and adipose tissue inflammation in a mouse model of high fat diet-induced obesity.2  Blocks ER stress-induced NLRP3 inflammasome activation and hepatocyte death.3 Attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mouse model.4

References/Citations

1) Xie et al. (2002), Effects of tauroursodeoxycholic acid on endoplasmic reticulum stress-induced caspase-12 activation; Hepatology, 36 592
2) Chen et al. (2016), Chemical chaperones reduce ER stress and adipose tissue inflammation in high fat diet-induced mouse model of obesity; Sco. Rep., 6 27486
3) Lebeaupin et al. (2015), ER stress induces NLRP3 inflammasome activation and hepatocyte death; Cell Death Dis., 6 e1879
4) Nunes et al. (2012), TUDCA, a bile acid, attenuates amyloid precursor protein processing and amyloid-β deposition in APP/PS1 mice; Mol. Neurobiol. 45 440

swipe
Image 1

Catalog#  10-2782-0500

$45.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
14605-22-2
Catalog Number:
10-2782
Activity:
ER stress inhibitor
Chemical Name:
3α,7β-Dihydroxy-5β-cholan-24-oic acid N-(2-sulfoethyl)amide
Alternate Names:
Tauroursodeoxycholic acid, sodium salt
Molecular Weight:
521.69
Molecular Formula:
C26H44NO6SNa
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
Physical Properties:
White solid
Purity:
95% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the TUDCA | ER stress inhibitor to your wish list.