TWS119 | GSK-3ß inhibitor

TWS119 chemical structure

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TWS-119 (601514-19-6) is a potent inhibitor of GSK-3ß (IC50 = 30 nM).1 At higher concentrations (400 nM), it induces neurogenesis in mouse embryonic stem cells.1 It maintained hepatic stellate cells in the quiescent state.2 TWS119 treatment increased the amount of stem cell-like memory CD8+ T cells3, enhanced metabolic fitness of CD8+ T cells4, and prevented CD8+ differentiation5. It displayed neuroprotective effects in models of cerebral ischemia.6,7 TWS199 greatly increased the efficacy of NK cells against myeloma.8

References/Citations:

  1. Ding et al. (2003), Synthetic small molecules that control stem cell fate; Proc. Natl. Acad. Sci. USA 100 7632
  2. Kordes et al. (2008), Canonical Wnt signaling maintains quiescent stage of hepatic stellate cells; Biochem. Biophys. Res. Commun. 367 116
  3. Forget et al. (2012), Stimulation of Wnt/ß-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype; PLoS One 7 e41074
  4. Sabatino et al. (2016), Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies; Blood 128 519
  5. Guan et al. (2018), Antigen-specific CD8+ memory stem T cells generated from human peripheral blood effectively eradicate allogeneic targets in mice; Stem Cell Res. Ther. 9 337
  6. Song et al. (2019), Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke; J. Neuroinflammation. 16 256
  7. Gao et al. (2021), GSK-3ß inhibitor TWS119 alleviates hypoxic-ischemic brain damage via a crosstalk with Wnt and Notch signaling pathways in neonatal rats; Brain Res. 1768 147588
  8. Ren et al. (2023), GSK-3ß/ß-catenin pathway plays crucial roles in the regulation of NK cell cytotoxicity against myeloma cells; FASEB J. 37 e22821
601514-19-6, GSK-3b inhibitor, GSK-3ß inhibitor, TWS-119, TWS119, TWS119 supplier

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TWS-119 (601514-19-6) is a potent inhibitor of GSK-3ß (IC50 = 30 nM).1 At higher concentrations (400 nM), it induces neurogenesis in mouse embryonic stem cells.1 It maintained hepatic stellate cells in the quiescent state.2 TWS119 treatment increased the amount of stem cell-like memory CD8+ T cells3, enhanced metabolic fitness of CD8+ T cells4, and prevented CD8+ differentiation5. It displayed neuroprotective effects in models of cerebral ischemia.6,7 TWS199 greatly increased the efficacy of NK cells against myeloma.8

References/Citations:

  1. Ding et al. (2003), Synthetic small molecules that control stem cell fate; Proc. Natl. Acad. Sci. USA 100 7632
  2. Kordes et al. (2008), Canonical Wnt signaling maintains quiescent stage of hepatic stellate cells; Biochem. Biophys. Res. Commun. 367 116
  3. Forget et al. (2012), Stimulation of Wnt/ß-catenin pathway in human CD8+ T lymphocytes from blood and lung tumors leads to a shared young/memory phenotype; PLoS One 7 e41074
  4. Sabatino et al. (2016), Generation of clinical-grade CD19-specific CAR-modified CD8+ memory stem cells for the treatment of human B-cell malignancies; Blood 128 519
  5. Guan et al. (2018), Antigen-specific CD8+ memory stem T cells generated from human peripheral blood effectively eradicate allogeneic targets in mice; Stem Cell Res. Ther. 9 337
  6. Song et al. (2019), Wnt canonical pathway activator TWS119 drives microglial anti-inflammatory activation and facilitates neurological recovery following experimental stroke; J. Neuroinflammation. 16 256
  7. Gao et al. (2021), GSK-3ß inhibitor TWS119 alleviates hypoxic-ischemic brain damage via a crosstalk with Wnt and Notch signaling pathways in neonatal rats; Brain Res. 1768 147588
  8. Ren et al. (2023), GSK-3ß/ß-catenin pathway plays crucial roles in the regulation of NK cell cytotoxicity against myeloma cells; FASEB J. 37 e22821