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Product Details

Tyrphostin 9 | PDGFR kinase inhibitor and Oxidative phosphorylation inhibitor

Tyrphostin 9 (10537-47-0) inhibits PDGF receptor tyrosine kinase (IC50 = 1.2 μM)1 and is a potent (10 nM) inhibitor of oxidative phosphorylation2. Inhibits cell growth by disrupting mitochondria3. Tyrphostin 9 perturbs the golgi complex and blocks proliferation of vascular smooth muscle cells4.

References/Citations
1) Bilder et al. (1991), Tyrphostins inhibit PDGF-induced DNA synthesis and associated early events in smooth muscle cells; Am. J. Physiol., 260 C721
2) Terada et al. (1981), The interaction of highly active uncouplers with mitochondria; Biochim. Biophys. Acta, 639 225
3) Burger et al. (1995), Tyrphostin AG17, [3,5-Ditert-butyl-4-hydroxybenzylidene)-malononitrile], inhibits cell growth by disrupting mitochondria; Cancer Res., 55 2794
4) Thyberg et al. (1998), Tyrphostin A9 and wortmannin perturb the Golgi complex and block proliferation of vascular smooth muscle cells; Eur. J. Cell Biol., 76 33

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Focus Biomolecules, Tyrphostin 9 structure | PDGFR kinase inhibitor & Oxidative phosphorylation inhibitor | CAS 10537-47-0

Catalog#  10-1535

$30.00
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CAS:
10537-47-0
Catalog Number:
10-1535
Activity:
PDGFR kinase inhibitor and OX Phosphorylation inhibitor
Alternate Names:
Tyrphostin a9, Malonoben, AG-17, SF 6847, RG-50872
Chemical Name:
3,5-Di-tert-butyl-4-hydroxybenzylidene-malononitrile
Molecular Weight:
282.38
Molecular Formula:
C18H22N2O
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml)
Physical Properties:
Orange solid
Purity:
99% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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