UAMC-4821 | Ferroptosis inhibitor

CAS:
 N/A
Catalog Number:
 10-4948

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UAMC-4821 is a next generation ferrostatin-like ferroptosis inhibitor with improved potency (IC50 = 5.2 nM), oral bioavailability, and the ability to cross the blood-brain barrier.  It displays good microsomal stability and low clearance in vivo in mice.

  1. Scarpellini et al. (2025), Oxazole-Based Ferroptosis Inhibitors with Promising Properties to Treat Central Nervous System Diseases; J. Med. Chem., 68 4908
Ferroptosis inhibitor, New ferrostatin, next gen ferrostatin, UAMC-4821, UAMC-4821 supplier, UAMC4821
CAS:
N/A
Catalog Number:
10-4948
Activity:
Ferroptosis inhibitor
Chemical Names:
N1-Cyclohexyl-4-(oxazol-5-yl)benzene-1,2-diamine
Molecular Weight:
257.34
Molecular Formula:

C15H19N3O

Solubility:
Soluble in DMSO (>50 mg/ml with warming)
Physical Properties:
Off-white/gray to pale yellow solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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UAMC-4821 is a next generation ferrostatin-like ferroptosis inhibitor with improved potency (IC50 = 5.2 nM), oral bioavailability, and the ability to cross the blood-brain barrier.  It displays good microsomal stability and low clearance in vivo in mice.

  1. Scarpellini et al. (2025), Oxazole-Based Ferroptosis Inhibitors with Promising Properties to Treat Central Nervous System Diseases; J. Med. Chem., 68 4908

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