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Product Details

UCF-101 | Omi/HtrA2 protease inhibitor

UCF-101 (313649-08-0) is a potent, specific, competitive, and reversible inhibitor of the pro-apoptotic, mitochondrial serine protease Omi/HtrA2 (IC50 = 9.5 μM for His-Omi134-458). Shows very little activity against various other serine proteases tested (IC50 ≥ 200 μM).1 Mitigates streptozotocin-induced cardiomyocyte dysfunction.2 Protects against cerebral oxidative injury and cognitive impairment in a rat model.3  Cell permeable.

References/Citations

1) Cilenti et al. (2003), Characteristics of a novel and specific inhibitor for the pro-apoptotic protease Omi/HtrA2; J. Biol. Chem., 278 11489
2) Li et al. (2009), UCF-101 mitigates streptozotocin-induced cardiomyocyte dysfunction: role of AMPK; Am. J. Physiol. Endocrinol. Metab., 297 E965
3) Hu et al. (2013), Ucf-101 protects against cerebral oxidative injury and cognitive impairment in septic rat; Int. Immunopharmacol., 16 108

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UCF-101 | 313649-08-0 | Structure | Supplier

Catalog#  10-1544-0005

$65.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
313649-08-0
Catalog Number:
10-1544
Activity:
Omi/HrtrA2 protease inhibitor
Chemical Name:
Dihydro-5[[5-(2-nitrophenyl)-2-furanyl]methylene]-1,3-diphenyl-2-thioxo-4,6(1H,5H)-pyrimidinedione
Molecular Weight:
495.51
Molecular Formula:
C27H17N3O5S
Solubility:
Soluble in DMSO (up to 30 mg/ml with warming) or in DMF (up to 25 mg/ml)
Physical Properties:
Orange solid
Purity:
98% by TLC
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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