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Product Details

UCPH-101 | EAAT1 inhibitor

UCPH-101 (1118460-77-7) is a potent (IC50 = 660 nM) and selective inhibitor of the excitatory amino acid transporter 1 (EAAT1).1,2 It induced cell death in glioblastoma cells via intracellular glutamate accumulation. UCPH-101 also significantly increased survival in glioma-bearing mice.3

References/Citations
1) Jensen et al. (2009), Discovery of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1; J. Med. Chem., 52 912
2) Erichsen et al. (2010), Structure-Activity Relationship Study of the First Selective Inhibitor of Excitatory Amino Acid Transporter Subtype 1: 2-Amino-4-(4-methoxyphenyl)-7-(naphthalen-1-yl)-5-oxo-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile (UCPH-101); J. Med. Chem., 53 7180
3) Corbetta et al. (2019), Altered function of the glutamate-aspartate transporter GLAST, a potential therapeutic target in glioblastoma; Int. J. Cancer, 144 2539

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Catalog#  10-4880-0005

$90.00
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CAS:
1118460-77-7
Catalog Number:
10-4880
Activity:
EAAT1 inhibitor
Chemical Name:
2-Amino-4-(4-methoxyphenyl)-7-naphthalen-1-yl-5-oxo-4,6,7,8-tetrahydrochromene-3-carbonitrile
Molecular Weight:
422.48
Molecular Formula:
C27H22N2O3
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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