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Product Details

Umifenovir | Broad-spectrum antiviral

Umifenovir (131707-23-8) is a broad-spectrum antiviral medication.1 It has shown activity against influenza A,B,and C, respiratory syncytial, SARS-CoV, adeno, parainfluenza type 5, polio, rhino, coxsackie, hanta, chikungungya, hepatitis B and C viruses.2,3 It blocks hemagglutinin-mediated membrane fusion of influenza virus particles.2 Umifenovir has recently been shown to inhibit SARS-CoV2 infection by blocking virus entry as well as release from endolysosomes during intracellular trafficking.5 It has been suggested that Umifenovir may block trimerization of the spike glycoprotein, a key step in host cell adhesion.6

References/Citations
1) Blasing et al. (2014), Arbidol as a broad-spectrum antiviral: an update; Antiviral Res, 107 84
2) Boriskin et al. (2008) Arbidol: a broad-spectrum antiviral compound that blocks viral fusion; Curr. Meed. Chem., 15 997
3) Brooks et al. (2012) Antiviral activity of Arbidol, a broad-spectrum drug for use against respiratory viruses, varies according to test conditions; J. Med. Virol., 84 170
4) Leneva et al. (2009) Characteristics of Arbidol-resistant mutants of influenza virus: Implications for the mechanism of anti-influenza action of arbidol; Antiviral Res., 81 132
5) Wang et al. (2020) The anti-influenza drug, arbidol, is an efficient inhibitor of SARS-CoV-2 in vitro; Cell Discov., 6 28
6) Vankadari (2020) Arbidol: A Potential Antiviral Drug for the Treatment of SARS-CoV-2 by Blocking Trimerization of the Spike Glycoprotein; Int. J. Antimicrob. Agents, 105998

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Umifenovir (CAS

Catalog#  10-4472-0010

$50.00
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CAS:
131707-23-8
Catalog Number:
10-4472
Activity:
Broad-spectrum antiviral
Chemical Name:
Ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate hydrochloride
Alternate Name:
Arbidol
Molecular Weight:
513.88
Molecular Formula:
C22H25BrN2O3S HCl
Solubility:
Soluble in DMSO (up to 15 mg/ml).
Physical Properties:
White solid
Purity:
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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