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UNC-2170 HCl | Methyl-lysine binding protein inhibitor

UNC-2170 (1648707-58-7), identified by screening, was found to be a μM ligand for 53BP1 which also demonstrated at least 17-fold selectivity for 53BP1 over other methyl-lysine binding proteins. The DNA damage response protein 53BP1 utilizes its tandem tudor domain to recognize dimethylated lysine 20 on histone (H4K20me2), a modification associated with double-strand DNA breaks. UNC-2170 functions as a 53BP1 antagonist in cell lysates and suppresses class switch recombination in whole cells, a process requiring a functioning 53BP1 tudor domain.1

References/Citations

1) Perfetti et al. (2015), Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein 53BP1; ACS Chem. Biol., 10 1072

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Focus Biomolecules supplier, chemical structure of UNC-2170 HCl | Methyl-lysine binding protein inhibitor | CAS 1648707-58-7

Catalog#  10-1558-0005

$90.00
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CAS:
1648707-58-7
Catalog Number:
10-1558
Activity:
Methyl-lysine binding protein inhibitor
Chemical Name:
3-Bromo-N-(3-(tert-butylamino)propyl)benzamide, hydrochloride
Molecular Weight:
349.69
Molecular Formula:
C14H21BrN2O • HCl
Solubility:
Soluble in DMSO (up to 40 mg/ml) or in Water (up to 50 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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