UNC9435 | TYRO3/MERTK inhibitor

CAS:
 3091640-25-1 (free base)
Catalog Number:
 10-4082

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25 mg$375.00
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UNC9435 (3091640-25-1 free base) is a potent dual inhibitor of TYRO3 (IC50 = 3.7 nM) and MERTK (IC50 = 1.1 nM), TAM family kinases with roles in oncogenesis and innate immunity.1 Displays 46-fold selectivity over the TAM kinase AXL and 120-fold selectivity over FLT3.  It inhibited colony formation in H1650 and H1975 NSCLC cell lines and inhibited efferocytosis.

References/Citations:

  1. Kong et al. (2025), Discovery of Novel TYRO3/MERTK Dual Inhibitors; J. Med. Chem., 68 8455
3091640-25-1, MERTK inhibitor, TAM family inhibitor, TYRO3 inhibitor, TYRO3/MERTK inhibitor, UNC9435, UNC9435 supplier
CAS:
3091640-25-1 (free base)
Catalog Number:
10-4082
Activity:
TYRO3/MERTK dual inhibitor
Chemical Names:
trans-4-((2-((3-Chlorophenyl)amino)-5-(1-(cyclopentylmethyl)-piperidin-4-yl)pyrimidine-4-yl)amino)cyclohexan-1-ol hydrochloride
Molecular Weight:
520.54
Molecular Formula:

C27H38ClN5O·HCl

Solubility:
Soluble in DMSO (4 mg/ml with warming) and water (5 mg/ml with warming)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months. Product is hygroscopic.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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UNC9435 (3091640-25-1 free base) is a potent dual inhibitor of TYRO3 (IC50 = 3.7 nM) and MERTK (IC50 = 1.1 nM), TAM family kinases with roles in oncogenesis and innate immunity.1 Displays 46-fold selectivity over the TAM kinase AXL and 120-fold selectivity over FLT3.  It inhibited colony formation in H1650 and H1975 NSCLC cell lines and inhibited efferocytosis.

References/Citations:

  1. Kong et al. (2025), Discovery of Novel TYRO3/MERTK Dual Inhibitors; J. Med. Chem., 68 8455

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