UR214-9 | Septin inhibitor

CAS:
 2456263-31-1
Catalog Number:
 10-4397

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UR214-9 (2456263-31-1) is an analog of Forchlorfenuron that was found to reduce HER2 and human epididymis protein 4 (HE4) levels and showed cytotoxicity against endometrial cancer via septin inhibition.1,2 It reduced ocular hypertension via disruption of the septin filament assembly in mice.3 UR214-9 induced mitochondrial fragmentation in macrophages in zebrafish larvae without altering mitochondrial mass leading to lytic cell death.4

References/Citations:

  1. Kim et al. (2020)Development of Potent Forchlorfenuron Analogs and Their Cytotoxic effect in Cancer Cell Lines, Sci. Rep., 10 3241
  2. Moore et al. (2020)Development of UR214-9, a novel septin inhibitor, for the treatment of endometrial cancer, Gynecol. Oncol., 159 Suppl. 1 231
  3. Maddala et al. (2024)Dysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension, JCI Insight, 9 e179468
  4. Brokatsky et al. (2025)Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214-9, on Mitochondrial Fragmentation and Lytic Cell Death, Cytoskeleton (Hoboken), July 30 2025
2456263-31-1, Septin inhibitor, UR214-9, UR214-9 supplier
CAS:
2456263-31-1
Catalog Number:
10-4397
Activity:
Septin inhibitor
Chemical Names:
N-(2,6-Dichloro-4-pyridinyl)-N’-[2-fluoro-3-(trifluoromethyl)phenyl]urea
Molecular Weight:
368.11
Molecular Formula:

C13H7Cl2F4N3O

Solubility:
Soluble in DMSO (45 mg/ml)
Physical Properties:
White solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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UR214-9 (2456263-31-1) is an analog of Forchlorfenuron that was found to reduce HER2 and human epididymis protein 4 (HE4) levels and showed cytotoxicity against endometrial cancer via septin inhibition.1,2 It reduced ocular hypertension via disruption of the septin filament assembly in mice.3 UR214-9 induced mitochondrial fragmentation in macrophages in zebrafish larvae without altering mitochondrial mass leading to lytic cell death.4

References/Citations:

  1. Kim et al. (2020)Development of Potent Forchlorfenuron Analogs and Their Cytotoxic effect in Cancer Cell Lines, Sci. Rep., 10 3241
  2. Moore et al. (2020)Development of UR214-9, a novel septin inhibitor, for the treatment of endometrial cancer, Gynecol. Oncol., 159 Suppl. 1 231
  3. Maddala et al. (2024)Dysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension, JCI Insight, 9 e179468
  4. Brokatsky et al. (2025)Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214-9, on Mitochondrial Fragmentation and Lytic Cell Death, Cytoskeleton (Hoboken), July 30 2025

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