UR214-9 | Septin inhibitor

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5 mg$75.00
25 mg$275.00
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UR214-9 (2456263-31-1) is an analog of Forchlorfenuron that was found to reduce HER2 and human epididymis protein 4 (HE4) levels and showed cytotoxicity against endometrial cancer via septin inhibition.1,2 It reduced ocular hypertension via disruption of the septin filament assembly in mice.3 UR214-9 induced mitochondrial fragmentation in macrophages in zebrafish larvae without altering mitochondrial mass leading to lytic cell death.4

References/Citations:

  1. Kim et al. (2020)Development of Potent Forchlorfenuron Analogs and Their Cytotoxic effect in Cancer Cell Lines, Sci. Rep., 10 3241
  2. Moore et al. (2020)Development of UR214-9, a novel septin inhibitor, for the treatment of endometrial cancer, Gynecol. Oncol., 159 Suppl. 1 231
  3. Maddala et al. (2024)Dysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension, JCI Insight, 9 e179468
  4. Brokatsky et al. (2025)Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214-9, on Mitochondrial Fragmentation and Lytic Cell Death, Cytoskeleton (Hoboken), July 30 2025
2456263-31-1, Septin inhibitor, UR214-9, UR214-9 supplier

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

UR214-9 (2456263-31-1) is an analog of Forchlorfenuron that was found to reduce HER2 and human epididymis protein 4 (HE4) levels and showed cytotoxicity against endometrial cancer via septin inhibition.1,2 It reduced ocular hypertension via disruption of the septin filament assembly in mice.3 UR214-9 induced mitochondrial fragmentation in macrophages in zebrafish larvae without altering mitochondrial mass leading to lytic cell death.4

References/Citations:

  1. Kim et al. (2020)Development of Potent Forchlorfenuron Analogs and Their Cytotoxic effect in Cancer Cell Lines, Sci. Rep., 10 3241
  2. Moore et al. (2020)Development of UR214-9, a novel septin inhibitor, for the treatment of endometrial cancer, Gynecol. Oncol., 159 Suppl. 1 231
  3. Maddala et al. (2024)Dysregulation of septin cytoskeletal organization in the trabecular meshwork contributes to ocular hypertension, JCI Insight, 9 e179468
  4. Brokatsky et al. (2025)Comparative Analysis of Septin Modifiers, Forchlorfenuron and UR214-9, on Mitochondrial Fragmentation and Lytic Cell Death, Cytoskeleton (Hoboken), July 30 2025