UZH2 | METTL3 inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $120.00 | ||
| 25 mg | $425.00 |
UZH2 (2756566-45-5) is a potent (IC50 = 5 nM) and selective (against METTL1 and METTL16) inhibitor of the RNA methyltransferase METTL3, a key component of the writer complex targeting N6-methyladenosine (m6A), the most common RNA modification. It was able to impair cell growth (GI50 = 12 µM) in MOLM-13 cancer cells (AML).
References/Citations:
- Dolbois, et al. (2021), 1,4,9-Triazaspiro[5.5]undecane-2-one Derivatives as Potent and Selective METTL3 Inhibitors; J. Med. Chem., 64 12738
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
UZH2 (2756566-45-5) is a potent (IC50 = 5 nM) and selective (against METTL1 and METTL16) inhibitor of the RNA methyltransferase METTL3, a key component of the writer complex targeting N6-methyladenosine (m6A), the most common RNA modification. It was able to impair cell growth (GI50 = 12 µM) in MOLM-13 cancer cells (AML).
References/Citations:
- Dolbois, et al. (2021), 1,4,9-Triazaspiro[5.5]undecane-2-one Derivatives as Potent and Selective METTL3 Inhibitors; J. Med. Chem., 64 12738
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