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Valinomycin | Induces loss of mitochondrial membrane potential

Valinomycin (2001-95-8) is a selective K+ ionophore capable of transporting potassium ions through lipid membranes.1 Valinomycin can induce apoptosis in cells by causing a rapid loss of mitochondrial membrane potential via potassium efflux.2,3

References/Citations
1) Pressman, (1976) Biological applications of ionophores; Annu. Rev. Biochem., 45 501
2) Furlong et al., (1998) Induction of apoptosis by valinomycin: mitochondrial permeability transition causes intracellular acidification; Cell Death Diff., 5 214
3) Inai et al. (1997) Valinomycin induces apoptosis of ascites hepatoma cells (AH-130) in relation to mitochondrial membrane potential; Cell Struc .Funct., 22 555

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Focus Biomolecules supplier, structure of Valinomycin | Induces loss of mitochondrial membrane potential | CAS 2001-95-8

Catalog#  10-2112

$42.00
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CAS:
2001-95-8
Catalog Number:
10-2112
Activity:
Induces loss of mitochondrial membrane potential
Chemical Name:
Cyclo(L-Val-D-HyIva-D-Val-L-Lac-)3
Molecular Weight:
1111.35
Molecular Formula:
C54H90N6O18
Solubility:
Soluble in DMSO (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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