Veratramine | Cyclopamine analog

CAS:
60-70-8
Catalog Number:
10-1147
Activity:
Cyclopamine analog
Chemical Name:
(3β, 23β)-14,15,16,17-Tetrahydroveratraman-3,23-diol
Alternate Names:
NSC 17821; NSC 23880
Molecular Weight:
409.60
Molecular Formula:
C27H39NO2
Solubility:
Soluble in DMSO (up to 12 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Available Options

Size :PriceQuantity 
5 mg$50.00
25 mg$200.00

Veratramine (60-70-8) is a teratogenic steroidal alkaloid found in the corn lily (Veratrum sp.).1,2 It is an analog of cyclopamine which can inhibit the hedgehog signaling pathway-dependent proliferation in NIH/3T3 cells at 8 μM.1  Cell permeable.

SPECIAL HANDLING PRECAUTIONS: This product is teratogenic. Women who are, or may be pregnant should not handle veratramine

References/Citations:

1) Tang et al. (2010), Antitumor and antiplatelet activity of alkaloids from veratrum dahuricum;  Phytother. Res., 24 821
2) Mahindroo et al. (2009), Hedgehog-Gli signaling pathway inhibitors as anticancer agents;  J. Med. Chem., 52 3829

CAS:
60-70-8
Catalog Number:
10-1147
Activity:
Cyclopamine analog
Chemical Name:
(3β, 23β)-14,15,16,17-Tetrahydroveratraman-3,23-diol
Alternate Names:
NSC 17821; NSC 23880
Molecular Weight:
409.60
Molecular Formula:
C27H39NO2
Solubility:
Soluble in DMSO (up to 12 mg/ml) or in Ethanol (up to 10 mg/ml)
Physical Properties:
Tan solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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