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Product Details

Veratridine | Na channel opener

Veratridine (71-62-5) is a steroidal alkaloid voltage-gated Na+ channel activator1. Veratridine may be used to increase Na+ concentration in cardiomyocytes2 and in cultured sympathetic neurons3. Toxic: LD50=1.35 mg/Kg (mouse i.p.)

References/Citations
1) Fekete et al. (2009), Mechanism of the persistent sodium current activator veratridine-evoked Ca elevation: implication for epilepsy; J. Neurochem., 111 745
2) Chen et al. (1997), Differential effects of Ca2+ channel blockers on Ca2+ overload induced by lysophosphatidylcholine in cardiomyocytes; Eur. J. Pharmacol., 333 261
3) Koike et al. (2000), Sodium overload through voltage-dependent Na(+) channels induces necrosis and apoptosis of rat superior cervical ganglion cells in vitro; Brain Res. Bull., 51 345

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Focus Biomolecules cell signaling reagent supplier, chemical structure of Veratridine | Na channel opener | CAS 71-62-5

Catalog#  10-1017

$50.00
Quantity
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CAS:
71-62-5
Catalog Number:
10-1017
Activity:
Na channel opener
Molecular Weight:
673.81
Molecular Formula:
C36H51NO11
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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