Vigabatrin | Anticonvulsant/Analgesic

Vigabatrin chemical structure

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Vigabatrin (68506-86-5) is a selective GABA transaminase (GABA-T) inhibitor thus increasing brain and CSF GABA levels.1 It prevents the development of morphine tolerance in mice.2 Displays analgesic effects in the acute thermal pain model in mice.3 It is a clinically useful anti-seizure agent.4

References/Citations:

  1. Larsson et al. (1986), Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes; Neuropharmacology 25 617
  2. Chavooshi et al. (2009), Vigabatrin attenuates the development and expression of tolerance to morphine-induced antinociception in mice; Pharmacol. Biochem. Behav. 93 155
  3. Jarogniew et al. (2008), Dose-response relationship analysis of vigabatrin doses and their antinociceptive effects in the hot-plate test in mice; Pharmacol. Rep. 60 409
  4. Ring et al. (1990), Vigabatrin: rational treatment for chronic epilepsy; J. Neurol. Neurosurg. Psychiatry 18 14085
68506-86-5, GABA transaminase inhibitor, GABA-T inhibitor, vigabatrin, Vigabatrin supplier
Alternate Name:
γ-Vinyl GABA

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Vigabatrin (68506-86-5) is a selective GABA transaminase (GABA-T) inhibitor thus increasing brain and CSF GABA levels.1 It prevents the development of morphine tolerance in mice.2 Displays analgesic effects in the acute thermal pain model in mice.3 It is a clinically useful anti-seizure agent.4

References/Citations:

  1. Larsson et al. (1986), Differential effect of gamma-vinyl GABA and valproate on GABA-transaminase from cultured neurones and astrocytes; Neuropharmacology 25 617
  2. Chavooshi et al. (2009), Vigabatrin attenuates the development and expression of tolerance to morphine-induced antinociception in mice; Pharmacol. Biochem. Behav. 93 155
  3. Jarogniew et al. (2008), Dose-response relationship analysis of vigabatrin doses and their antinociceptive effects in the hot-plate test in mice; Pharmacol. Rep. 60 409
  4. Ring et al. (1990), Vigabatrin: rational treatment for chronic epilepsy; J. Neurol. Neurosurg. Psychiatry 18 14085