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Vildagliptin | DPPIV inhibitor

Vildagliptin (274901-16-5) is a potent inhibitor of dipeptidyl peptidase IV (DPP IV), an enzyme that cleaves glucagon-like peptide 1 (GLP-1).1 Delaying the degradation of GLP-1  extends the action of insulin and suppressing the release of glucagon which results in reduction in elevated blood glucose levels (hyperglycemia).2 Clinically useful antidiabetic agent. Ameliorates cognitive deficits in streptozotocin-induced Alzheimers disease model.3 Displays protective effects on β-cells by inhibition of ER stress in a mouse model.4

References/Citations

1) Balas et al. (2007), The dipeptidyl peptidase IV inhibitor vildagliptin suppresses endogenous glucose production and enhances islet function after single-dose administration in type 2 diabetic patients;  J. Clin. Endocrinol. Metab., 92 1249
2) Ahren et al. (2004), Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels and reduces glucagon levels in type 2 diabetes;  J. Clin. Emdocrinol. Metab., 89 2078
3) Kosaraju et al. (2013), Vildagliptin: an anti-diabetes agent ameliorates cognitive deficits and pathology observed in streptozotocin-induced Alzheimer’s disease;  J. Pharm. Pharmacol., 65 1773
4) Shimizu et al. (2012), DPP4 inhibitor vildagliptin preserves  β-cell mass through amelioration of endoplasmic reticulum stress in C/EBPB transgenic mice;  J. Mol. Endocrinol., 49 125

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Catalog#  10-2887

$44.00
Quantity
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CAS:
274901-16-5
Catalog Number:
10-2887
Activity:
DPP4 inhibitor
Chemical Name:
(S)-1-[N-(3-Hydroxy-1-adamantyl)glycyl]pyrrolidine-2-carbonitrile
Alternate Names:
LAF237
Molecular Weight:
303.40
Molecular Formula:
C17H25N3O2
Solubility:
Soluble in DMSO (up to 45 mg/ml), in DMF (up to 20 mg/ml), or in Ethanol (up to 20 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 2 years as supplied. Solutions in DMSO, DMF, or ethanol may be stored at -20°C for up to 3 months
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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