Violacein | Immunostimulant

CAS:
 548-54-9
Catalog Number:
 10-5073
Violacein chemical structure

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Violacein (548-54-9) displays immunostimulatory effects via the TLR8 receptor.1 Induces death of Ras-mutated melanoma cells via down-regulation of HDAC6, AXL and AKT inhibiting autophagy.2 Induces apoptosis in breast cancer cells by upregulating Bax, p53 and down regulating MDM2.3 Displays protective effects in an ALS model.4

References/Citations:

  1. Venegas al. (2019), The Bacterial Product Violacein Exerts an Immunostimulatory Effect Via TLR8; Sci. Rep., 9 13661
  2. Goncalves et al. (2016), Violacein induces death of RAS-mutated metastatic melanoma by impairing autophagy process; Tumour Biol., 37 14049
  3. Alshatwi et al. (2016), Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2; Exp. Toxicol. Pathol., 68 89
  4. Olivera-Bravo et al. (2022), Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis; Sci. Rep. 12 4439
548-54-9, violacein, Violacein supplier
CAS:
548-54-9
Catalog Number:
10-5073
Activity:
Immunostimulant
Chemical Names:
(E)-3-(5-(5-Hydroxy-1H-indol-3-yl)-2-oxo-1H-pyrrol-3(2H)-ylidene)indolin-2-one
Molecular Weight:
343.34
Molecular Formula:

C20H13N3O3

Solubility:
Soluble in DMSO (Slightly soluble warm)
Physical Properties:
Violet-blue solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Download Safety Data Sheet

Product Data Sheet:

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Violacein (548-54-9) displays immunostimulatory effects via the TLR8 receptor.1 Induces death of Ras-mutated melanoma cells via down-regulation of HDAC6, AXL and AKT inhibiting autophagy.2 Induces apoptosis in breast cancer cells by upregulating Bax, p53 and down regulating MDM2.3 Displays protective effects in an ALS model.4

References/Citations:

  1. Venegas al. (2019), The Bacterial Product Violacein Exerts an Immunostimulatory Effect Via TLR8; Sci. Rep., 9 13661
  2. Goncalves et al. (2016), Violacein induces death of RAS-mutated metastatic melanoma by impairing autophagy process; Tumour Biol., 37 14049
  3. Alshatwi et al. (2016), Violacein induces apoptosis in human breast cancer cells through up regulation of BAX, p53 and down regulation of MDM2; Exp. Toxicol. Pathol., 68 89
  4. Olivera-Bravo et al. (2022), Neuroprotective effects of violacein in a model of inherited amyotrophic lateral sclerosis; Sci. Rep. 12 4439

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