VT103 | TEAD molecular glue

CAS:
 2290608-13-6
Catalog Number:
 10-4296
VT103 chemical structure

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VT103 (2290608-13-6) inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts the interaction between YAP/TAZ and TEAD via inhibition of TEAD1 (IC50 = 1 nM).1 It prevented TAC-induced cardiac hypertrophy and dysfunction in WT mice by blocking the interaction of TEAD1 with BRD4.2 VT103 enhanced the efficacy of dabrafenib in KTOR81 lung adenocarcinoma cells and xenograft models.3 VT103 acts a molecular glue between TEAD and the transcriptional repressor VGLL4 leading to antagonism of YAP activity.4

References/Citations:

  1. Tang et al. (2021), Small-molecule inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma; Mol. Cancer Ther. 20 986
  2. Song et al. (2024), TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cell remodeling through BRD4/Wnt4 pathway; Signal Transduct. Target. Ther. 9 45
  3. Hosoya et al. (2025), Novel TEAD1 Inhibitor VT103 Enhances Dabrafenib Efficacy in BRAF V600E Mutated Lung Adenocarcinoma via Survivin Downregulation; Cancer Sci. 116 1883
  4. Guarnaccia et al. (2025), TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway; Proc. Natl. Acad. Sci. USA 122 e2425984122
2290608-13-6, TEAD inhibitor, TEAD molecular glue, VT-103, VT103, VT103 supplier
CAS:
2290608-13-6
Catalog Number:
10-4296
Activity:
TEAD inhibitor and molecular glue
Chemical Names:
N-Methyl-3-(1-methylimidazol-4-yl)-4-[4-(trifluoromethyl)anilino]benzenesulfonamide
Molecular Weight:
410.42
Molecular Formula:

C18H17F3N4O2S

Solubility:
Soluble in DMSO (at least 40 mg/ml)
Physical Properties:
Off-white solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ room temperature. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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VT103 (2290608-13-6) inhibits YAP/TAZ-TEAD promoted gene transcription, blocks TEAD auto-palmitoylation, and disrupts the interaction between YAP/TAZ and TEAD via inhibition of TEAD1 (IC50 = 1 nM).1 It prevented TAC-induced cardiac hypertrophy and dysfunction in WT mice by blocking the interaction of TEAD1 with BRD4.2 VT103 enhanced the efficacy of dabrafenib in KTOR81 lung adenocarcinoma cells and xenograft models.3 VT103 acts a molecular glue between TEAD and the transcriptional repressor VGLL4 leading to antagonism of YAP activity.4

References/Citations:

  1. Tang et al. (2021), Small-molecule inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma; Mol. Cancer Ther. 20 986
  2. Song et al. (2024), TEA domain transcription factor 1(TEAD1) induces cardiac fibroblasts cell remodeling through BRD4/Wnt4 pathway; Signal Transduct. Target. Ther. 9 45
  3. Hosoya et al. (2025), Novel TEAD1 Inhibitor VT103 Enhances Dabrafenib Efficacy in BRAF V600E Mutated Lung Adenocarcinoma via Survivin Downregulation; Cancer Sci. 116 1883
  4. Guarnaccia et al. (2025), TEAD-targeting small molecules induce a cofactor switch to regulate the Hippo pathway; Proc. Natl. Acad. Sci. USA 122 e2425984122

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