VU0134992 | Kᵢᵣ4.1 Blocker

VU0134992 chemical structure Focus Biomolecules

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VU0134992 (755002-90-5) is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats  suggesting therapeutic blood pressure lowering potential.  It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2

References/Citations:

  1. Kharade (2018), Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker VU0134992; Mol. Pharmacol. 94 926
  2. Lu et al. (2022), Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity; Cell. Mol. Life Sci. 79 296
755002-90-5, Kir4.1 blocker, VU-0134992, VU0134992, VU0134992 supplier

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

VU0134992 (755002-90-5) is a blocker of the inward rectifier potassium channel Kir4.1 (IC50 = 970 nM).1 It also inhibits Kir3.1/3.2, Kir3.1/3.4, and Kir4.2 with similar potency. VU0134992 induced diuresis, natriuresis, and kaliuresis in Sprague-Dawley rats  suggesting therapeutic blood pressure lowering potential.  It reduced polymyxin-induced nephrotoxicity in cell culture and mouse explant kidney tissue.2

References/Citations:

  1. Kharade (2018), Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker VU0134992; Mol. Pharmacol. 94 926
  2. Lu et al. (2022), Inwardly rectifying potassium channels mediate polymyxin-induced nephrotoxicity; Cell. Mol. Life Sci. 79 296

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