WC522 | Dvl-cholesterol interaction inhibitor
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 5 mg | $80.00 | ||
| 25 mg | $280.00 |
WC522 blocks the cholesterol-dishevelled interaction leading to inhibition of ß-catenin signaling. It specifically inhibits the Dvl2-PDZ-cholesterol interaction (IC50 = 40 nM) leading to suppression of both Wnt-independent and Wnt-stimulated ß-catenin signaling (IC50 = 150 nM). WC522 inhibits cell proliferation in APC-truncated colorectal carcinoma cells and colorectal carcinoma HCT15 xenografts in mice.
References/Citations:
- Sharma et al. (2025), Cholesterol-targeting Wnt-ß-catenin signaling inhibitors for colorectal cancer; Nat. Chem. Biol. 21 1376
C24H32N2O2
>98% HPLC
NMR: (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
WC522 blocks the cholesterol-dishevelled interaction leading to inhibition of ß-catenin signaling. It specifically inhibits the Dvl2-PDZ-cholesterol interaction (IC50 = 40 nM) leading to suppression of both Wnt-independent and Wnt-stimulated ß-catenin signaling (IC50 = 150 nM). WC522 inhibits cell proliferation in APC-truncated colorectal carcinoma cells and colorectal carcinoma HCT15 xenografts in mice.
References/Citations:
- Sharma et al. (2025), Cholesterol-targeting Wnt-ß-catenin signaling inhibitors for colorectal cancer; Nat. Chem. Biol. 21 1376
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