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Product Details

WHI-P131 | JAK3 inhibitor

WHI-P131 (202475-60-3) is a JAK3 inhibitor. Inhibits human glioblastoma cell adhesion and invasion.1 Increases survival in a mouse ALS model.2 Delays or prevents autoimmune type 1 diabetes in NOD mice.3 Exhibits potent anti-inflammatory activity in mouse models of peritonitis, colitis, cellulitis and systemic inflammatory response syndrome.4 Displays protective effects against myocardial ischemia and reperfusion injury in mouse models.5

1) Narla et al. (1998), Inhibition of human glioblastoma cell adgesion and invasion by 4-(4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P131) and 4-(3’-bromo-4’-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline (WHI-P154); Mol. Clin. Cancer Res., 4 2463
2) Trieu et al. (2000), A specific inhibitor of janus kinase-3 increases survival in a transgenic mouse model of amyotrophic lateral sclerosis; Biochem. Biophys. Res. Commun., 267 22
3) Cetkovic-Cvrlje et al. (2003), Targeting JAK3 with JANEX-1 for prevention of autoimmune type 1 diabetes in NOD mice; Clin. Immunol., 106 213
4) Uckun et al. (2008), Anti-inflammatory activity profile of JANEX-1 in preclinical animal models; Bioorg. Med. Chem., 16 1287
5) Oh et al. (2013), Inhibition of Janus activated kinase-3 protects against myocardial ischemia and reperfusion injury in mice; Exp. Mol. Med., 45 e23 

Focus Biomolecules cell signaling reagent supplier, chemical structure of WHI-P131 | JAK3 inhibitor | CAS 202475-60-3

Catalog#  10-1190

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Catalog Number:
JAK3 inhibitor
Alternate Names:
Chemical Name:
Molecular Weight:
Molecular Formula:
C16H15N3O3 HCl
Soluble in DMSO (up to 50 mg/ml).
Physical Properties:
Yellow solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Protect from moisture. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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