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Product Details

WIN-55212-2 mesylate | Cannabinoid CB1/CB2 agonist

WIN-55212-2 mesylate (131543-23-2) is a high affinity cannabinoid receptor agonist (Ki = 62.3 nM for recombinant human CB1 and 3.3 nM for recombinant human CB2)1 with analgesic2 and anti-inflammatory activities. WIN-55212-2 mesylate activates p42 and p44 MAP kinase via cannabinoid receptor-mediated receptor signaling.3

References/Citations
1) Felder et al. (1995), Comparison of the pharmacology and signal transduction of the human cannabinoid CB1 and CB2 receptors; Mol. Pharmacol., 48 443
2) Herzberg et al. (1997), The analgesic effects of R(+)-WIN 55,212-2 mesylate, a high affinity cannabinoid agonist in a rat model of neuropathic pain; Neurosci. Lett., 221 157
3) Bouaboula et al. (1995), Activation of mitogen-activated protein kinases by stimulation of the central cannabinoid receptor CB1; Biochem. J., 312 637

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WIN-55212-2 mesylate | 131543-23-2 | Structure | Supplier

Catalog#  10-2002

$70.00
Quantity
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CAS:
131543-23-2
Catalog Number:
10-2002
Activity:
Cannabinoid CB1/CB2 agonist
Chemical Name:
(R)-(+)-[2,3-Dihydro-5-methyl-3-(4-morpholinylmethyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone mesylate
Molecular Weight:
522.62
Molecular Formula:
C27H26N2O3 CH3SO3H
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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