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Product Details

Wortmannin | PI3K inhibitor

Wortmannin (19545-26-7) is a potent and selective inhibitor of PI3-kinase which acts via covalent modification of Lys-802.2 Inhibits autophagy in rat hepatocytes.3 Inhibits adipocyte differentiation of 3T3-L1 cells.4 Wortmannin is useful tool for probing PI3-K-mediated cellular events.5

1) Holleran et al. (2003), Use of high-performance liquid chromatography to characterize the rapid decomposition of wortmannin in tissue culture media; Anal. Biochem., 323 19
2) Wymann et al. (1996), Wortmannin inactivates phosphoinositide 3-kinase by covalent modification of Lys-802, a residue involved in the phosphate transfer reaction; Mol. Cell. Biol., 16 1722
3) Blommaart et al. (1997), The phosphatidylinositol 3-kinase inhibitors wortmannin and LY294002 inhibit autophagy in isolated rat hepatocytes; Eur. J. Biochem., 243 240
4) Tomiyama et al. (1995), Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells; Biochem. Biophys. Res. Commun., 212 263
5) Ui et al. (1995), Wortmannin as a unique probe from an intracellular signaling protein, phosphoinositide 3-kinase; Trends Biochem. Sci., 20 303

Focus Biomolecules cell signaling reagent supplier, chemical structure of Wortmannin | PI3K inhibitor | CAS 19545-26-7

Catalog#  10-2115

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Catalog Number:
PI3K inhibitor
Chemical Name:
Fermentation product
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 25 mg/ml).
Physical Properties:
White or off-white solid
98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 1 year as supplied. Dried aliquots evaporated from ethanol may be stored at -20° for several months. Solutions however are not stable and must be used within one working day. Note: Wortmannin decomposes fairly quickly in culture me
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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