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WY-14643 | PPAR alpha agonist

WY-14643 (50892-23-4) is a selective PPARα agonist (EC50=0.63, 32 and >100 µM for PPARα,γ and δ, respectively).1  Displays anti-inflammatory activity2 and reduces LPS-induced inflammation in alveolar epithelial cells3. Induces “browning” of white adipocytes in combined treatment with retinoic acid.4  Stimulates ADAM10-mediated proteolysis of  amyloid precursor protein in a mouse model.5 Down regulates NFkB transcriptional activity. Review.6

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References/Citations
1) Forman et al. (1997), Hypolipidemic drugs, polyunsaturated fatty acids and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta; Proc. Natl. Acad. Sci. USA, 94 4312
2) Devchand et al. (1996), The PPARalpha-leukptriene B4 pathway to inflammation control; Nature, 384 39
3) Heckler et al. (2015), PPAR-a activation reduced LPS-induced inflammation in aveolar epithelial cells; Exp. Lung Res., 41 393
4) Wang et al. (2015), WY14643 combined with all-trans retinoic acid acts via p38 MAPK to induce “browning” of white adipocytes in mice; Genet. Mol. Res., 14 6978
5) Corbett et al. (2015), Activation of peroxisome proliferator-activated receptor alpha stimulates ADAM10-mediated proteolysis of APP; Proc. Natl. Acad. Sci. USA, 112 8445
6) Merk et al. (2015), Pirinixic acids: flexible fatty acid mimetics with various biological activities; Future Med. Chem., 7 1597

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WY-14643 | 50892-23-4 | Structure | Supplier

Catalog#  10-1137

$60.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
50892-23-4
Catalog Number:
10-1137
Activity:
PPAR α agonist
Alternate Names:
Pirinixic acid
Chemical Name:
4-Chloro-6-(2,3-xylidino)-2-pyrimidinylthioacetic acid
Molecular Weight:
323.8
Molecular Formula:
C14H14ClN2O2S
Solubility:
Soluble in DMSO (up to 40 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
RT (des.)
Stability:
Stable for 5 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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