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WZB117 | Glucose transport inhibitor

WZB117 (1223397-11-2) is an inhibitor of Glucose Transporter 1 (GLUT1). It inhibited cell proliferation in lung cancer A549 cells and breast cancer MCF7 cells with an IC50 of approximately 10 μM. Daily intraperitoneal injection of WZB117 at 10mg/kg resulted in 70% reduction in tumor volume of human A549 lung cancer grafted on nude mice

References/Citations
1) Liu et al. (2012), A small-molecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo; Mol. Cancer Ther., 11 1672

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Focus Biomolecules cell signaling supplier, chemical structure of WZB117 | Glucose transport inhibitor | CAS 1223397-11-2

Catalog#  10-4581

$45.00
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CAS:
1223397-11-2
Catalog Number:
10-4581
Activity:
Glucose transport inhibitor
Chemical Name:
3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate)
Molecular Weight:
368.31
Molecular Formula:
C20H13FO6
Solubility:
Soluble in DMSO (greater than 25 mg/ml) or in Ethanol (greater than 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may br stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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