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Product Details

Xanthohumol | VCP inhibitor / Autophagy inhibitor

Xanthohumol (6754-58-1) binds to the N-terminal domain of valosin-containing protein (VCP), an essential protein for autophagosome maturation. Xanthohumol inhibits the function of VCP thereby impairing autophagosome maturation and resulting in accumulation of the microtubule-associated protein 1 light chain 3-II (LC3-II)1. Impairs prostate cancer cell growth and proliferation2. Cell permeable.

References/Citations
1) Sasazawa et al. (2012), Xanthohumol impairs autophagosome maturation through direct inhibition of valosin-containing protein; ACS Chem. Biol., 7 892
2) Vene et al. (2012), Xanthohumol impairs prostate cancer cell growth and invasion and dimishes the incidence and progression of advanced tumors in TRAMP mice; Mol. Med., 18 1292

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Focus Biomolecules cell signaling reagent supplier, structure of Xanthohumol | VCP / Autophagy inhibitor | CAS 6754-58-1

Catalog#  10-1188

$140.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
6754-58-1
Catalog Number:
10-1188
Activity:
VCP inhibitor / Autophagy inhibitor
Molecular Weight:
354.41
Molecular Formula:
C21H22O5
Solubility:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 35 mg/ml).
Physical Properties:
Yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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