my account
Login
  Loading... Please wait...

Product Details

XAV-939 | Tankyrase inhibitor, Cardiomyogenesis inducer

XAV-939 (284028-89-3) is a tankyrase inhibitor (IC50=11 and 4 nM for TNKS1 and 2 respectively).  Antagonizes wnt signaling via stimulation of β-catenin degradation and stabilization of actin.1  XAV-939 robustly induces cardiomyogenesis of stem cells.2  Cell permeable

References/Citations

1) Huang et al. (2009), Tankyrase inhibition stabilizes axin and antagonizes Wnt signaling; Nature, 46 614 
2) Wang et al. (2011), Cardiac induction of embryonic stem cells by a small molecule inhibitor of Wnt/β-catenin signaling; Chem. Biol., 6 192

swipe
XAV-939 | 284028-89-3 | Structure | Supplier

Catalog#  10-1186

$45.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
284028-89-3
Catalog Number:
10-1186
Activity:
Tankyrase inhibitor / Cardiomyogenesis inducer
Chemical Name:
2-[4-(Trifluoromethyl)phenyl]-7,8-dihydro-5H-thino[4,3-d]pyrimidin-4-ol
Molecular Weight:
312.31
Molecular Formula:
C14H11F3N2OS
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
White or off-white solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
Room temperature
Stability:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the XAV-939 | Tankyrase inhibitor, Cardiomyogenesis inducer to your wish list.