XIB4035 | GFRα-1 agonist

CAS:
10023-54-8
Catalog Number:
10-1486
Activity:
GFRα1 agonist
Chemical Name:
(E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine 3(H3PO4)
Molecular Weight:
750.45
Molecular Formula:
C26H31Cl2N3 3(H3PO4)
Solubility:
Soluble in DMSO (up to 25 mg/ml with warming).
Physical Properties:
Light brown solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Available Options

size :PriceQuantity 
5 mg$60.00
25 mg$240.00

XIB4035 (10023-54-8) is a novel small molecule thought to be an agonist at the glial cell line-derived neurotrophic factor (GDNF) family receptor GFRα-1. It inhibits radiolabeled GDNF binding in Neuro-2A cells in a concentration dependent manner IC50 = 10.4 μM. Like GDNF, XIB4035 induced Ret autophosphorylation and promoted neurite outgrowth in Neuro-2A cells.1 Recent studies indicate that it enhances GFRα family receptor signaling in conjunction with ligand stimulation. Effective treatment for small-fiber neuropathy in mouse models of the disease.2,3  GDNF agonists may be a new class of Parkinson’s disease therapeutics.4

References/Citations:

1) Tokugawa et al. (2003), XIB4035, a novel nonpeptidyl small molecule agonist for GFRα-1; Neurochem. Int., 42 81
2) Hedstrom et al. (2014), Treating small fiber neuropathy by topical application of a small molecule modulator of ligand-induced GFRα/RET receptor signaling; Proc. Natl. Acad. Sci. USA, 111 2325
3) Hsieh et al. (2018) Distinct TrkA and Ret modulated negative and positive neuropathic behaviors in a mouse model of resiniferatoxin-induced small fiber neuropathy; Exp. Neurol. 300 87
4) Drinkut et al. (2016) Ret is essential to mediate GDNF’s neuroprotective and neuroregenerative effect in Parkinson disease mouse model; Cell Death Dis., 7 e2359

CAS:
10023-54-8
Catalog Number:
10-1486
Activity:
GFRα1 agonist
Chemical Name:
(E)-N4-(7-chloro-2-(2-chlorostyryl)quinolin-4-yl)-N1,N1-diethylpentane-1,4-diamine 3(H3PO4)
Molecular Weight:
750.45
Molecular Formula:
C26H31Cl2N3 3(H3PO4)
Solubility:
Soluble in DMSO (up to 25 mg/ml with warming).
Physical Properties:
Light brown solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
RT
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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