Y-320 | IL-17 inhibitor

CAS:
 288250-47-5
Catalog Number:
 10-4276
Y-320 chemical structure

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Y-320 (288250-47-5) is an inhibitor of IL-17 production (IC50 = 20 – 60 nM in CD4 T cells).1 It significantly inhibited the development and progression of arthritis and joint destruction in collagen-induced arthritis models. Y-320 acted synergistically with other chemotherapeutic agents to overcome multidrug resistance.2  It also enhances premature termination codon (PTC) readthrough resulting in increased protein levels and protein synthesis.3 Y-320 also acts as a potent oral sialylation inhibitor (IC50 = 200 nM in PDAC cells).4 It suppressed α-2,3/2,6-sialylation inhibiting PDAC tumor growth and remodeling the tumor microenvironment.  Y-320 acted synergistically with anti-PD-1 therapy to overcome immune checkpoint blockade resistance.

References/Citations:

  1. Ushio et al. (2013), A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys; Pharmaceuticals (Basel), 7 1
  2. Hong et al. (2020), Y-320, a novel immune-modulator, sensitizes multidrug-resistant tumors to chemotherapy; Am. J. Transl. Res., 12 551
  3. Hosseini-Farahabadi et al. (2021), Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough; PLoS Biol., 19 e3001221
  4. Mou et al. (2025), A Potent Oral Sialylation Inhibitor Augments the Immunotherapy in Pancreatic Ductal Adenocarcinoma; ACS Cent. Sci., 11 1969
288250-47-5, IL-17 inhibitor, Y-320, Y-320 supplier, Y320
CAS:
288250-47-5
Catalog Number:
10-4276
Activity:
IL-17 inhibitor
Chemical Names:
1-(4-Chlorophenyl)-N-[3-cyano-4-(4-morpholin-4-ylpiperidin-1-yl)phenyl]-5-methylpyrazole-4-carboxamide
Molecular Weight:
505.02
Molecular Formula:

C27H29ClN6O2

Solubility:
Soluble in DMSO (18 mg/ml with warming)
Physical Properties:
Pale pink solid
Purity:

>98% HPLC
NMR: (Conforms)

Storage Temperature:
-20°C
Stability:
Stable for up to 2 years when stored as supplied @ -20°C. Solutions in DMSO may be stored at -20°C for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

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Product Data Sheet:

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Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

Y-320 (288250-47-5) is an inhibitor of IL-17 production (IC50 = 20 – 60 nM in CD4 T cells).1 It significantly inhibited the development and progression of arthritis and joint destruction in collagen-induced arthritis models. Y-320 acted synergistically with other chemotherapeutic agents to overcome multidrug resistance.2  It also enhances premature termination codon (PTC) readthrough resulting in increased protein levels and protein synthesis.3 Y-320 also acts as a potent oral sialylation inhibitor (IC50 = 200 nM in PDAC cells).4 It suppressed α-2,3/2,6-sialylation inhibiting PDAC tumor growth and remodeling the tumor microenvironment.  Y-320 acted synergistically with anti-PD-1 therapy to overcome immune checkpoint blockade resistance.

References/Citations:

  1. Ushio et al. (2013), A New Phenylpyrazoleanilide, Y-320, Inhibits Interleukin 17 Production and Ameliorates Collagen-Induced Arthritis in Mice and Cynomolgus Monkeys; Pharmaceuticals (Basel), 7 1
  2. Hong et al. (2020), Y-320, a novel immune-modulator, sensitizes multidrug-resistant tumors to chemotherapy; Am. J. Transl. Res., 12 551
  3. Hosseini-Farahabadi et al. (2021), Small molecule Y-320 stimulates ribosome biogenesis, protein synthesis, and aminoglycoside-induced premature termination codon readthrough; PLoS Biol., 19 e3001221
  4. Mou et al. (2025), A Potent Oral Sialylation Inhibitor Augments the Immunotherapy in Pancreatic Ductal Adenocarcinoma; ACS Cent. Sci., 11 1969

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