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Product Details

YC-1 | Soluble guanylyl cyclase activator

YC-1 (170632-47-0) is a nitric oxide-independent activator of soluble guanylyl cyclase (sGC). Significantly elevates cGMP levels and inhibits collagen-stimulated aggregation of rabbit platelets (IC50 = 14.6 μM).1 Induces human endometrial cancer cell senescence via modulation of HIF1α activity.2 Induces degradation of HIF1α.3 Protects against glutamate-induced neuronal damage4 and β-amyloid-induced toxicity in differentiated PC12 cells5.

1) Martin et al. (2001), YC-1 activation of human soluble guanylyl cyclase has both heme-dependent and heme-independent components; Proc. Natl. Acad. Sci. USA, 98 12938
2) Kato et al. (2006), Induction of human endometrial cancer cell senescence through modulation of HIF-1alpha activity by EGLN1; Int. J. Cancer, 118 1144
3) Kim et al. (2006), A domain responsible for HIF-1alpha degradation by YC-1, a novel anticancer agent; Int. J. Oncol., 29 255
4) Tai et al. (2018), Therapeutic window for YC-1 following glutamate-induced neuronal damage and transient focal cerebral ischemia; Mol. Med. Rep., 17 6490
5) Tsai et al. (2013), The role of heat shock protein 70 in the protective effect of YC-1 on β-amyloid-induced toxicity in differentiated PC12 cells.; PLoS One, 8(7) e69320

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Catalog#  10-1581-0005

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Catalog Number:
Soluble guanylyl cyclase activator
Chemical Name:
Alternate Name:
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 35 mg/ml) or in Ethanol (up to 15 mg/ml).
Physical Properties:
Pink solid
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20° (des.)
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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