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YM-155 | Survivin inhibitor

CAS:
781661-94-7
Catalog Number:
10-1473
Activity:
Survivin inhibitor
Alternate Names:
Sepantronium bromide
Chemical Name:
1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
Molecular Weight:
443.3
Molecular Formula:
C20H19BrN4O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Tan to yellow solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1 Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2 Induces DNA damage.3 YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4

References/Citations:

1) Nakahara et al. (2007), YM155, a novel small-molecule surviving suppressant, induces regression of established human hormone-refractory prostate tumor xenografts; Cancer Res. 67 8014
2) Okamoto et al. (2012), Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin; Mol.Cancer Ther. 11 204
3) Glaros et al. (2012), The ‘survivin suppressants’ NSC 80467 and YM 155 induce a DNA damage response; Cancer Chemother. Pharmacol. 70 207
4) Wang et al. (2014), Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma; Apoptosis 19 748

YM-155 | Survivin inhibitor is also available in the Cellular Metabolism Library.
CAS:
781661-94-7
Catalog Number:
10-1473
Activity:
Survivin inhibitor
Alternate Names:
Sepantronium bromide
Chemical Name:
1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
Molecular Weight:
443.3
Molecular Formula:
C20H19BrN4O3
Solubility:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Tan to yellow solid
Purity:
>98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

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