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Product Details

YM-155 | Survivin inhibitor

YM-155 (781661-94-7) is a novel small molecule survivin suppressant. YM-155 suppresses expression of survivin (a member of the IAP family) and induced apoptosis in human tumor cell lines at 10 nmol/L with little effect on other IAP or Bcl-2 family members.1 Overcomes erlotinib resistance in EGFR mutation-positive non-small cell lung cancer.2 Induces DNA damage.3 YM-155 induces an autophagy-dependent cell death in adenoid cystic carcinoma cells.4

1) Nakahara et al. (2007), YM155, a novel small-molecule surviving suppressant, induces regression of established human hormone-refractory prostate tumor xenografts; Cancer Res. 67 8014
2) Okamoto et al. (2012), Overcoming erlotinib resistance in EGFR mutation-positive non-small cell lung cancer cells by targeting survivin; Mol.Cancer Ther. 11 204
3) Glaros et al. (2012), The 'survivin suppressants' NSC 80467 and YM 155 induce a DNA damage response; Cancer Chemother. Pharmacol. 70 207
4) Wang et al. (2014), Induction of autophagy-dependent cell death by the survivin suppressant YM155 in salivary adenoid cystic carcinoma; Apoptosis 19 748

Focus Biomolecules cell signaling reagent supplier, chemical structure of YM-155 | Survivin inhibitor | CAS 781661-94-7

Catalog#  10-1473

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Catalog Number:
Survivin inhibitor
Alternate Names:
Sepantronium bromide
Chemical Name:
1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 25 mg/ml).
Physical Properties:
Tan to yellow solid
>98% by TLC
NMR (Conforms)
Storage Temperature:
Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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