Z-Leu-Leu-Leu-vinylsulfone | Proteasome inhibitor

10-4990 ZLeuLeuLeuVS chemical structure

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200 µg$175.00
1 mg$695.00
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Protease Inhibitors

Z-Leu-Leu-Leu-vinylsulfone (193482-47-2) blocks the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptidase activity in isolated proteasomes and in living cells via covalent modification of active site threonine residues.1,2

References/Citations:

  1. Bogyo et al. (1997), Covalent modification of the active site threonine of proteasomal ß subunits and the Escherichia coli homolog HsIV by a new class of inhibitors; Proc. Natl. Acad. Sci. USA 94 6629
  2. Powers et al. (2002); Irreversible inhibitors of serine, cysteine, and threonine proteases, Chem. Rev., 102 4639
193482-47-2, Z-Leu-Leu-Leu-vinylsulfone, Z-Leu-Leu-Leu-vinylsulfone supplier, Z-Leu-Leu-Leu-VS, ZL3VS
Alternate Name:
ZL3VS; Z-Leu-Leu-Leu-VS

Safety Data Sheet:

N/A

Product Data Sheet:

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Z-Leu-Leu-Leu-vinylsulfone (193482-47-2) blocks the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptidase activity in isolated proteasomes and in living cells via covalent modification of active site threonine residues.1,2

References/Citations:

  1. Bogyo et al. (1997), Covalent modification of the active site threonine of proteasomal ß subunits and the Escherichia coli homolog HsIV by a new class of inhibitors; Proc. Natl. Acad. Sci. USA 94 6629
  2. Powers et al. (2002); Irreversible inhibitors of serine, cysteine, and threonine proteases, Chem. Rev., 102 4639