Z-Leu-Leu-Leu-vinylsulfone | Proteasome inhibitor
Available Options
| Size | Price | Quantity | |
|---|---|---|---|
| 200 µg | $175.00 | ||
| 1 mg | $695.00 |
Z-Leu-Leu-Leu-vinylsulfone (193482-47-2) blocks the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptidase activity in isolated proteasomes and in living cells via covalent modification of active site threonine residues.1,2
References/Citations:
- Bogyo et al. (1997), Covalent modification of the active site threonine of proteasomal ß subunits and the Escherichia coli homolog HsIV by a new class of inhibitors; Proc. Natl. Acad. Sci. USA 94 6629
- Powers et al. (2002); Irreversible inhibitors of serine, cysteine, and threonine proteases, Chem. Rev., 102 4639
C28H45N3O6S
>98% TLC
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Z-Leu-Leu-Leu-vinylsulfone (193482-47-2) blocks the trypsin-like, chymotrypsin-like, and peptidylglutamyl peptidase activity in isolated proteasomes and in living cells via covalent modification of active site threonine residues.1,2
References/Citations:
- Bogyo et al. (1997), Covalent modification of the active site threonine of proteasomal ß subunits and the Escherichia coli homolog HsIV by a new class of inhibitors; Proc. Natl. Acad. Sci. USA 94 6629
- Powers et al. (2002); Irreversible inhibitors of serine, cysteine, and threonine proteases, Chem. Rev., 102 4639
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Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
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