my account
Login
  Loading... Please wait...

Product Details

Z-Phe-Tyr-CHO | Cathepsin L inhibitor

A potent and selective inhibitor of cathepsin L, IC50=0.85 nM 1 selective over  cathepsin B and calpain II (IC50s=85.1 and 184 nM respectively). Suppresses osteoclastic  pit formation at 1.5 nM and markedly inhibited parathyroid hormone-stimulated osteoclastic bone resorption.2 Also inhibits cathepsin K (Kis=0.052 and 1.57 nM for cat L and cat K respectively) and partially provides the basis for the finding that cathepsin K is the protease responsible for osteoclastic bone resorption.3 Provides partial protection against serum and potassium deprivation-induced neuronal death.4 Active in vivo.2

References/Citations

1) Woo et al. (1995), Peptidyl aldehyde derivatives as potent and selective inhibitors of cathepsin L; Bioorg. Med. Chem. Lett., 5 1501
2) Woo et al. (1996), Suppressive effect of N-(benzyloxycarbonyl)-L-phenylalanyl-L-tyrosinal on bone resorption in vitro and in vivo; Eur. J. Pharmacol., 300 131
3) James et al. (2001) Potent and selective cathepsin L inhibitors do not inhibit human osteoclast resoption in vitro; J. Biol. Chem., 276 11507
4) Kaasik et al. (2005), Up regulation if lysosomal cathepsin L and autophagy during neuronal death induced by reduced serum and potassium; Eur. J. Neurosci., 22 1023

swipe
Focus Biomolecules cell signaling supplier, chemical structure of Z-Phe-Tyr-CHO | Cathepsin L inhibitor | CAS 167498-29-5

Catalog#  10-3079-0001

$30.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
Request Bulk Quote
CAS:
167498-29-5
Catalog Number:
10-3079
Activity:
Cathepsin L inhibitor
Alternate Names:
Z-FY-CHO; Z-Phe-Tyr-Aldehyde; SB-412515
Molecular Weight:
446.50
Molecular Formula:
C26H26N2O5
Solubility:
Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 50 mg/ml)
Physical Properties:
Off-white to pale yellow solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

Connect with Focus

Click the button below to add the Z-Phe-Tyr-CHO | Cathepsin L inhibitor to your wish list.