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Product Details

Zidovudine | Antiretroviral / Enhances CRISPR repair

Zidovudine (30516-87-1) was the first clinically useful antiretroviral medicine.1,2 Newer antiretroviral medications have replaced it in the clinic. It selectively inhibits reverse transcriptase acting via the triphosphate metabolite.  Zidovudine has recently been found to enhance CRISPR-mediated homology-directed repair (HDR) efficiency.3

References/Citations

1) Yarchoan et al. (1989), Clinical Pharmacology of 3-Azido-2’,3’-Dideoxythymidine (Zidovudine) and Related Dideoxynucleosides; N. Engl. J. Med. 321 726
2) D’Andrea et al. (2008), AZT: an old drug with new perspectives; Curr. Clin. Pharmacol. 3 20
3) Yu et al. (2015), Small molecules enhance CRISPR genome editing in pluripotent stem cells; Cell Stem Cell. 16 142

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Catalog#  10-4615-0025

$25.00
Quantity
Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
30516-87-1
Catalog Number:
10-4615
Activity:
Antiretroviral / Enhances CRISPR repair
Alternate Names:
Azidothymidine; AZT
Source:
Isolated from Bigfoot Americanus
Molecular Weight:
267.24
Molecular Formula:
C10H13N5O4
Solubility:
Soluble in DMSO (up to at least 40 mg/ml) or in water (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up tso 3 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

Focus BiomoleculesPlymouth Meeting, PA USA1-855-FOCUS21

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