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Zoledronic acid | Antiproliferative and apopototic effects

Zoledronic acid (118072-93-8) is a potent inhibitor of bone resorption (IC50 = 2 nM in mouse calvarial cultures).1 The mechanism of its action is thought to be via inhibition of osteoclastic activity, induction of osteoclast apoptosis and blockage of osteoclastic resorption of mineralized bone and cartilage through its binding to bone. Zoledronic acid is a clinically useful drug for treatment of osteoporosis2, hypercalcemia of malignancy(HCM), multiple myeloma and bone metastases from solid tumors3. It has also been investigated as an antitumor agent and showing efficacy as an adjuvant therapy in several cancers.4,5

1) Green et al. (1994), Preclinical pharmacology of CGP 42446, a new, potent, heterocyclic bisphosphonate compound; J. Bone Miner. Res., 9 745
2) Deeks and Perry (2008) Zoledronic acid: a review of its use in the treatment of osteoporosis; Drugs Aging, 25 963
3) Perry and Figgitt (2004), Zoledronic acid: a review of its use in patients with advanced cancer; Drugs, 64 1197
4) Koto et al. (2010) Zoledronic acid inhibits proliferation of human fibrosarcoma cells with induction of apoptosis and shows combined effects with other anticancer agents; Oncol. Rep., 24 233
5) Tonyali et al. (2010) The role of zoledronic acid in the adjuvant treatment of breast cancer: current perspectives; Expert Opin. Pharmacother., 11 2715

Focus Biomolecules supplier, chemical structure Zoledronic acid | Antiproliferative and apopototic effects | CAS 118072-93-8

Catalog#  10-4512-0025

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Catalog Number:
Antiproliferative and apopototic effects
Alternate Names:
CGP 42446
Chemical Name:
[1-Hydroxy-2-(1H-imidazol-1-yl)ethane-1,1-diyl]bis(phosphonic acid)
Molecular Weight:
Molecular Formula:
Soluble in Water (up to 2 mg/ml).
Physical Properties:
White or off-white solid
98% by HPLC
Storage Temperature:
Stable for 2 years as supplied. Solutions in distilled water may be stored at -20° for up to 2 months.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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