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Zolmitriptan | Serotonin 5HT1B/1D receptor agonist / Regenerative activity

Zolmitriptan (CAS 139264-17-8) is a potent and selective serotonin 5HT 1B/1D agonist (Ki=0.63 and 5.01 nM for 5HT 1D and 1B respectively.1 Displays proven efficacy for the treatment of migraine.2 Inhibits neurogenic inflammation and pain during electrical stimulation in human skin.3 Induces nerve growth, integration and function in transplanted heterologous organs in regenerative medicine.4

References/Citations

1) Pauwels et al. (1997), How efficacious are 5-HTB/D receptor ligands: an answer from GTP gamma S binding studies with stably transfected C6-glial cell lines; Pharmacol., 36 499
2) Martin et al. (1997), Receptor specificity and trigemino-vascular inhibitor actions of a novel 5HT1B/1D receptor partial agonist, 311C90 (zolmitriptan);  Br. J. Pharmacol., 121 157
3) Doring et al. (2015), Zolmitriptan inhibits neurogenic inflammation and pain during electrical stimulation in human skin; Eur. J. Pain, 19 966
4) Blackiston et al. (2017), Serotonergic stimulation induces nerve growth and promotes visual learning via posterior eye grafts in a vertebrate model of induced sensory plasticity;  Regenerative Med., 2 8

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Focus Biomolecules supplier, chemical structure of Zolmitriptan | Serotonin 5HT1B/1D receptor agonist | CAS 139264-17-8

Catalog#  10-2663-0010

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CAS:
139264-17-8
Catalog Number:
10-2663
Activity:
Serotonin 5HT1B/1D receptor agonist / Regenerative activity
Chemical Name:
(4S)-4-((3-(2-(Dimethylamino)ethyl)-1H-indol-5-yl)methyl)-2-oxazolidinone
Alternate Names:
BW 311C90
Molecular Weight:
287.36
Molecular Formula:
C16H21N3O2
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 25 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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