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Angiogenesis

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  • 17-AAG | 75747-14-7 | Structure | Supplier
    $50.00
    17-AAG (75747-14-7) is a semi-synthetic analog of geldanamycin (Cat.# 10-1084) which is less toxic and more stable. 17-AAG selectively binds to and inhibits HSP90 from tumor cells. Anti-angiogenic activity. Cell permeable...

  • 17-DMAG | 150270-08-9 | Structure | Supplier
    $50.00
    17-DMAG (150270-08-9) is an analog of geldanamycin (Cat.# 10-1084) that displays superior pharmacological properties. 17-DMAG inhibits HSP90 and induces apoptosis in a variety of tumor cell lines. Inhibits angiogenesis. Cell...

  • AAL-993 | 269390-77-4 | Structure | Supplier
    $110.00
    AAL-993 (269390-77-4) inhibits VEGFR-1 (IC50 = 130 nM), VEGFR-2 (IC50 = 23 nM), and VEGFR-3 (IC50 = 18 nM). PDGFR-β, cKit, and CSF-1R are also inhibited at higher concentrations (IC50's 640 nM, 236 nM and 380 nM...

  • Bortezomib | Proteasome inhibitor
    $50.00
    Potent and selective proteasome inhibitor (Ki=0.6 nM). Inhibits proliferation of a number of tumor cell lines (IC50=7 nM).  Inhibits TNFα synthesis and FGF-induced angiogenesis. Clinically useful agent for...

  • Difluoromethylornithine HCl | Inhibits polyamine biosynthesis
    $30.00
    Difluoromethylornithine HCl (96020-91-6) is a selective inhibitor of ornithine decarboxylase.1 Induces apoptosis in a variety of cells.2 Difluoromethylornithine HCl displays cancer chemopreventive activity...

  • FAK inhibitor 14 | FAK inhibitor
    $45.00
    FAK inhibitor 14 (4506-66-5) is a selective focal adhesion kinase (FAK) inhibitor that displays no significant activity at a range of other kinases including EGFR, PDGFR and IGF-RI. Prevents FAK autophosphorylation at Y397...

  • Fumagillin | 23110-15-8 | Structure | Supplier
    $75.00
    Fumagillin (23110-15-8) is a natural product isolated from the microbial organism Aspergillus fumigatus and used as an antimicrobial for honey bees. It covalently binds and inhibits methionine aminopeptidase-2.1 Fumagillin...

  • Herboxidiene | 142861-00-5 | Structure | Supplier
    $80.00
    Herboxidiene (142861-00-5) is a novel polyketide fermentation product produced by Streptomyces chromofuscus, originally discovered by screening for herbicidal activity. Potent and selective inhibitor of spliceosome subunit...

  • Lenalidomide | Immunomodulator
    $50.00
    Lenalidomide (191732-72-6) is a thalidomide analog which, like thalidomide1, binds to cereblon which is the substrate recognition component of a cullin-dependent ubiquitin ligase and inhibits its autoubiquitination activity2...

  • Lenvatinib | VEGFR inhibitor
    $55.00
    Lenvatinib (417716-92-8) is a potent inhibitor of VEGFR2 and R3, IC50s=4.0 and 5.2 nM respectively.1  Also inhibits VEGFR1, FGFR1, PDGFR3b and Kit, IC50s=22, 46, 39 and 100 nM respectively.1 Suppresses lymph node and...

  • Sorafenib | Inhibitor of Raf-1 and other kinases
    $40.00
    Sorafenib (475207-59-1; base) was initially developed as a Raf kinase inhibitor, IC50 = 6 nM, but has been shown to inhibit many receptor tyrosine kinases including BRAF (IC50 = 22 nM); VEGFR-2 (IC50 = 90 nM); VEGFR-3 (IC50...

  • SU-1498 | VEGFR kinase inhibitor
    $55.00
    SU-1498 (168835-82-3) is a potent, reversible, selective inhibitor of VEGFR-2, also known as Flk-1 (IC50 = 700 nM). Inhibition of VEGFR-2 blocks angiogenesis in both in vitro and in vivo models. Cell permeable...

  • Thalidomide | 50-35-1 | Structure | Supplier
    $50.00
    Thalidomide (50-35-1) binds to the E3 ubiquitin ligase complex formed between CRBN, DDB1 and Cul4A, and inhibits the ligase activity. Inhibits TNF synthesis and FGF-induced angiogenesis. Cell permeable. Handle with caution,...

  • Vandetanib | VEGFRK inhibitor
    $40.00
    Vandetanib (443913-73-3) is a potent and selective inhibitor of  VEGFR2, ( KDR IC50 = 40 nM). Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500...

  • Vatalanib 2HCl | VEGFRK inhibitor
    $50.00
    Vatalanib 2HCl (212141-51-0) is a potent, selective inhibitor of the VEGFR tyrosine kinases VEGFR-1 (Flt-1, IC50 = 77 nM) and VEGFR-2 (FLK-1/KDR, IC50 = 37 nM).1 Weaker inhibitor of other tyrosine kinases including...

  • Zebularine | DNA methylation inhibitor
    $50.00
    Zebularine (3690-10-6) is an orally active DNA methyltransferase inhibitor. Inhibits tumor cell proliferation (IC50 = 120 μM) and re-activates silenced genes in T24 bladder carcinoma cells. Zebularine inhibits cytidine...

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