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ROS

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  • 3-Aminobenzamide | 3544-24-9 | Structure | Supplier
    $50.00
    3-Aminobenzamide (3544-24-9) inhibits endogenous poly-ADP-ribosyltransferases1. Inhibits nitric oxide-induced apoptosis but not differentiation in HL-60 cells2. Inhibits stress-induced apoptosis3. 3-Aminobenzamide has been...

  • AI-1 | 75483-04-4 | Structure | Supplier
    $70.00
    AI-1 (75483-04-4) is a novel antioxidant response element (ARE) activator which activates Nrf2 by covalently modifying Keap1 (Kelch-like ECH-associated protein 1) a negative regulator of Nrf2. Modification of Cys151 of Keap1...

  • AI-3 | 882288-28-0 | Structure | Supplier
    $75.00
    AI-3 (882288-28-0) is an activator of antioxidant response element (ARE) which induces cytoprotective genes in human cells. It alkylates Keap1 at Cys151 and is reactive toward additional cysteines at higher concentrations...

  • Ambroxol HCl | Free radical scavenger
    $50.00
    Ambroxol HCl (18683-91-5) is a radical scavenger with anti-inflammatory activity. Blocks the generation of reactive oxygen species by bronchoalveolar lavage cells, inhibits doxorubicin-induced lipid peroxidation (70 mg/kg in...

  • Apigenin | 520-36-5 | Structure | Supplier
    $36.00
    Apigenin (520-36-5) is a plant flavonoid with antioxidant properties. It has been reported to have myriad effects on biochemical pathways including kinase inhibition (CK2, PKC, ERK)1-3, CYP2CP inhibition4, inhibition of...

  • bis-BHT | Antioxidant-phenolic
    $35.00
    bis-BHT (118-82-1) is a potent antioxidant. Cell permeable. References/Citations1) Amorati et al. (2003), Antioxidant activity of 0-bisphenols: the role of intramolecular hydrogen bonding; J. Org. Chem. 68...

  • Bleomycin sulfate | Fibrosis-inducing agent
    $90.00
    Bleomycin sulfate (9041-93-4) coordinates with metals producing reactive oxygen species which causes oxidative damage to DNA1 and RNA2. Commonly used to induce lung fibrosis in animal disease models.3,4 Anticancer agent in...

  • CAPE | Inhibits NFkB activation
    $30.00
    CAPE (104594-70-9) is an antioxidant that inhibits NFκB activation and the growth of transformed cells. CAPE inhibits lipid peroxidation and displays antiinflammatory activity. Cell permeable. References/Citations1)...

  • Carnosic acid | Antioxidant
    $40.00
    Carnosic acid (3650-09-7) is an antioxidant and free radical scavenger. Increases cellular levels of glutathione (GSH) and prevents 6-hydroxydopamine-induced cell death in SH-SY5Y cells1. Carnosic acid-stimulation of GSH...

  • Celastrol | Proteasome inhibitor
    $116.00
    Celastrol (34157-83-0) displays potent antioxidant and anti-inflammatory activity. Inhibits NFkB (IC50=270 nM).  It induces heat shock response and cytoprotection in various cells. Inhibits 20S proteasome chymotrypsin...

  • CHS-828 | NAMPT inhibitor
    $50.00
    CHS-828 (200484-11-3) is a potent and selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in the biosynthesis of NAD, which may be used to deplete cells of NAD.1 Displays potent...

  • CYPMPO | Spin trap
    $40.00
    CYPMPO (934182-09-9) is a free radical spin-trap with hydroxyl and superoxide free radical trapping capabilities similar to DEPMPO (Cat.# 10-4502). Better solubility and increased half-life in aqueous buffers can give CYPMPO...

  • Decylubiquinone | MPTP inhibitor
    $48.00
    Decylubiquinone (55486-00-5) inhibits the Ca2+ dependent mitochondrial permeability transition pore (MPTP) without inhibiting respiration.1 Maximum effect on Ca2+ retention capacity of rat liver mitochondria at 100 μM...

  • Dehydrozingerone | Glutathione sponge
    $35.00
    Dehydrozingerone (1080-12-2) is a structural half analog of curcumin (Cat.# 10-1243) and is isolated from ginger rhizomes. Dehydrozingerone displays antioxidant, antibacterial and antifungal properties.1 It has also been...

  • DEPMPO | Spin trap
    $95.00
    DEPMPO (157230-67-6) is a spin trap capable of detecting oxygen, nitrogen, sulfur and carbon-centered free radicials both in vitro and in vivo. DEPMPO is useful for distinguishing between superoxide-dependent pathways of...

  • DIPPMPO | Spin Trap
    $125.00
    DIPPMPO (157230-67-6) is a more lipophilic analog of the widely used spin trap agent DEPMPO.1 It displays similar efficiency to DEPMPO in trapping various free radicals. Superoxide and hydroxyl adducts are slightly more...

  • DMNQ | Induces ROS generation
    $65.00
    DMNQ (6956-96-3) is a non-alkylating redox cycling quinone. A useful tool for studying reactive oxidant species and oxidative stress. Cellular effects are dependent on concentration and cell type. References/Citations1)...

  • DMPO | Spin trap
    $45.00
    DMPO (3317-61-1) is a hydrophilic spin trap for superoxide, O-, C-, S- and N-centered free radicals. DMPO is useful for both in vivo and in vitro studies. Cell Permeable. References/Citations1) Nishizawa et al. (2004),...

  • Ebselen | Glutathione peroxidase mimic
    $28.00
    Ebselen (60940-34-3) is a novel nontoxic selenium-containing multifunctional antioxidant and anti-inflammatory agent.1 Displays protective effects in reperfusion injury and stroke.2 Ebselen is an excellent...

  • Entacapone | COMT inhibitor - anti-Parkinsons
    $40.00
    Entacapone (130929-57-6) is a potent catechol O-methyltransferase (COMT) inhibitor (IC50 = 14.3, 20.1 and 73.3 nM for rat liver soluble COMT, total COMT and membrane-bound COMT respectively).1 Increases bioavailability of...

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