27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild cognitive impairment.1,2 Endogenous selective estrogen receptor modulator3 and ligand for the liver X receptor(EC50M = 85nM for LXR7alpha; and 71nM for LXRβ)4.
1) Heverin >i>et al. (2004), Changes in the levels of cerebral and extracerebral sterols in the brains of patients with Alzheimer's disease; J. Lipid Res., 45 186
2) Shafaati et al. (2011), Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670-671 mutation; J. Lipid Res., 52 1004
3) Umetani et al. (2007), 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen; Nature Medicine, 13 1185
4) Fu et al. (2001), 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells; J. Biol.Chem., 276 38378