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27-Hydroxycholesterol | Cholesterol oxidation metabolite

27-Hydroxycholesterol (20380-11-4) is a metabolite resulting from the action of sterol 27-hydroxylase on cholesterol. Concentrations of 27-hydroxycholesterol are elevated in patients with Alzheimers disease and mild cognitive impairment.1,2 Endogenous selective estrogen receptor modulator3 and ligand for the liver X receptor(EC50M = 85nM for LXR7alpha; and 71nM for LXRβ)4.

References/Citations
1) Heverin >i>et al. (2004), Changes in the levels of cerebral and extracerebral sterols in the brains of patients with Alzheimer's disease; J. Lipid Res., 45 186
2) Shafaati et al. (2011), Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670-671 mutation; J. Lipid Res., 52 1004
3) Umetani et al. (2007), 27-Hydroxycholesterol is an endogenous SERM that inhibits the cardiovascular effects of estrogen; Nature Medicine, 13 1185
4) Fu et al. (2001), 27-Hydroxycholesterol is an endogenous ligand for liver X receptor in cholesterol-loaded cells; J. Biol.Chem., 276 38378

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Catalog#  10-4536

$40.00
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CAS:
20380-11-4
Catalog Number:
10-4536
Activity:
Cholesterol oxidation metabolite
Chemical Name:
27-Hydroxycholesterol; 5,25R-Cholesten-3β,26-diol
Molecular Weight:
402.66
Molecular Formula:
C27H46O2
Solubility:
Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
White solid
Purity:
98% by HPLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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