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A-196 | SUV420H1/H2 methyltransferase inhibitor

A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.

References/Citations

1) Bromberg et al. (2017), The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity; Nat. Chem. Biol. 13 317

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Catalog#  10-4018-0005

$70.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
1982372-88-2
Catalog Number:
10-4018
Activity:
SUV420H1/H2 methyltransferase inhibitor
Chemical Name:
Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine
Molecular Weight:
359.25
Molecular Formula:
C18H16Cl2N4
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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