A-196 | SUV420H1/H2 methyltransferase inhibitor

CAS:
1982372-88-2
Catalog Number:
10-4018
Activity:
SUV420H1/H2 methyltransferase inhibitor
Chemical Name:
Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine
Molecular Weight:
359.25
Molecular Formula:
C18H16Cl2N4
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Available Options

Size:PriceQuantity 
5 mg$70.00
25 mg$270.00

A-196 (1982372-88-2) is a potent and selective (over 29 other methyltransferases) inhibitor of the protein lysine methyltransferases SUV420H1(IC50 = 25 nM) and SUV420H2 (IC50 = 144 nM). It substantially inhibited non-homologous end-joining (NHEJ)-directed DNA repair but not homology-directed repair(HDR) in cells treated with ionizing radiation. A-196 is active in cells and displayed no toxicity in several cell lines.

References/Citations:

1) Bromberg et al. (2017), The SUV4-20 inhibitor A-196 verifies a role for epigenetics in genomic integrity; Nat. Chem. Biol. 13 317

CAS:
1982372-88-2
Catalog Number:
10-4018
Activity:
SUV420H1/H2 methyltransferase inhibitor
Chemical Name:
Cyclopentyl-(6,7-dichloro-4-pyridin-4-yl-phthalazin-1-yl)-amine
Molecular Weight:
359.25
Molecular Formula:
C18H16Cl2N4
Solubility:
Soluble in DMSO (up to 5 mg/ml)
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°C
Stability:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.
Shipping Code:
RT

Safety Data Sheet:

N/A

Product Data Sheet:

Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee

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