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A77 1726 | DHODH inhibitor

A77 1726 (108605-62-5) is a pyrimidine biosynthesis inhibitor and immunomodulator.1 Inhibits the mitochondrial dihydroorotate dehydrogenase (DHODH).2 Leflunomide (Cat.# 10-2369) is rapidly metabolized in human hepatocytes to A77 1726.3 Cell permeable.

References/Citations
1) Manna et al. (1999), Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression; J. Immunol., 162 2095
2) Davis et al. (1996), immunosuppressive metabolite of leflunomide is a potent inhibitor of human dihydroorotate dehydrogenase; Biochemistry, 35 1270
3) Seah et al. (2008), Oxidative bioactivation and toxicity of leflunomide in immortalized human hepatocytes and kinetics of the non-enzymatic conversion to its major metabolite, A77 1726; Drug Metab. Lett., 2 153

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Focus Biomolecules cell signaling reagent supplier, chemical structure of A77 1726 | DHODH inhibitor | CAS 108605-62-5

Catalog#  10-1436

$45.00
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CAS:
108605-62-5
Catalog Number:
10-1436
Activity:
DHODH inhibitor
Alternate Names:
Teriflunomide
Chemical Name:
2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
Molecular Weight:
270.21
Molecular Formula:
C12H9F3N2O2
Solubility:
Soluble in DMSO (up to 30 mg/ml), or in Ethanol (up to 5 mg/ml with warming).
Physical Properties:
White solid
Purity:
98% by TLC
NMR (Conforms)
Storage Temperature:
-20°
Stability:
Stable for 2 years as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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