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Product Details

Actinomycin D | Transcription inhibitor

Actinomycin D (50-76-0) is a cyclopeptide antibiotic and intercalating transcription inhibitor with anti-neoplastic activity. Potent inhibitor of RNA polymerase.1 Induces apoptosis in a variety of cancer cell lines2,3via the intrinsic pathway4.  Upregulates proapoptotic PUMA and downregulates Bcl-2 mRNA in peripheral blood lymphocytes.5

1) Wagner et al.(2013) RNA Polymerase II acts as an RNA-dependent RNA polymerase to extend and destablize a non-coding RNA ; EMBO J. 32 781

2) J. Kleeff et al. (2000) Actinomycin D induces apoptosis and inhibits growth of pancreatic cancer cells; Int. J. Cancer, 86 399
3) Kasim et al. (2013) Live fluorescence and transmission-through-dye microscopic study of actinomycin D-induced apoptosis and apoptotic volume decrease ; Apoptosis, 18 521
4) Liu et al. (2016) Actinomycin D enhances killing of cancer cells by immunotoxin RG7787 through activation of the extrinsic pathway of apoptosis; Proc. Natl. Acad. Sci. USA, 113 10666
5) Kalousec et al. (2007) Actinomycin D upregulates proapoptotic protein Puma and downregulates Bcl-2 mRNA in normal peripheral blood lymphocytes; Anticancer Drugs, 18 763
6) Matsuzaka et al. (2016) Characterization and functional analysis of extracellular vesicles and muscle-abundant miRNA in C2C12 myocytes and Mdx mice; PLoS One 11(12) e0167811 [Focus Biomolecules Citation]

Focus Biomolecules supplier, chemical structure of Actinomycin D | Transcription inhibitor | CAS 50-76-0

Catalog#  10-2054

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Catalog Number:
Transcription inhibitor
Molecular Weight:
Molecular Formula:
Soluble in DMSO (up to 2 mg/ml) or in Ethanol (up to 10 mg/ml).
Physical Properties:
Orange-red solid
Storage Temperature:
Stable for 1 year as supplied. Protect from exposure to light and moisture. Solutions are not stable and must be made fresh and used within one working day. Do not store solutions.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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