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Product Details

Alamethicin | Pore-forming antimicrobial peptide

Alamethicin (27061-78-5) is a membrane permeabilizing, pore-forming agent.1 Applications include: [32P] incorporation into phosphatidylinositols2, permeabilization of sarcoplasmic reticulum vesicles3 and mitochondria4 and induction of lipid vesicle fusion.

References/Citations

1) Woolley et al. (2007), Channel-forming activity of alamethicin: effects of covalent tethering; Biodivers., 4 1323
2) Quist et al. (1989), Regulation of polyphosphoinositide synthesis in cardiac membranes; Arch. Biochem. Biophys., 271 21
3) Nakagawa et al. (1986), Adenylate cyclase in sarcoplasmic reticulum of skeletal muscle: distribution orientation and regulation; J. Cyclic Nuc. Prot. Phosphor. Res., 11 237
4) Korge et al. (2016), Reactive oxygen species production in cardiac mitochondria after complex I inhibition: Modulation by substrate-dependent regulation of the NADH/NAD(+) ratio; Free Radic. Biol. Med., 96 22

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Catalog#  10-2055-0001

$35.00
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Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee.
 
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CAS:
27061-78-5
Catalog Number:
10-2055
Activity:
Pore-forming antimicrobial peptide
Alternate Names:
U-22324
Molecular Weight:
1964.31
Molecular Formula:
C92H150N22O25
Solubility:
Soluble in DMSO (up to 25 mg/ml) or in Methanol (up to 10 mg/ml).
Physical Properties:
Off-white solid
Purity:
98% by TLC (mixture of alamethicin homologs)
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stability:
Stable for 1 year as supplied. Solutions in DMSO or methanol may be stored at -20°C for up to 3 months.
Shipping Code:
RT
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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