Alamethicin (27061-78-5) is a membrane permeabilizing, pore-forming agent.1 Applications include: [32P] incorporation into phosphatidylinositols2, permeabilization of sarcoplasmic reticulum vesicles3 and mitochondria4 and induction of lipid vesicle fusion.
1) Woolley et al. (2007), Channel-forming activity of alamethicin: effects of covalent tethering; Biodivers., 4 1323
2) Quist et al. (1989), Regulation of polyphosphoinositide synthesis in cardiac membranes; Arch. Biochem. Biophys., 271 21
3) Nakagawa et al. (1986), Adenylate cyclase in sarcoplasmic reticulum of skeletal muscle: distribution orientation and regulation; J. Cyclic Nuc. Prot. Phosphor. Res., 11 237
4) Korge et al. (2016), Reactive oxygen species production in cardiac mitochondria after complex I inhibition: Modulation by substrate-dependent regulation of the NADH/NAD(+) ratio; Free Radic. Biol. Med., 96 22