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Blasticidin S HCl | Antibiotic selection agent

Blasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1 Inhibits translation by trapping deformed tRNA on the ribosome.1 The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in Pseudomonas aeruginosa PA14.2 Selection agent for bis, bsr and bsd transformed cells.3,4


1) Svidritskiy et al., (2013), Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome; Proc. Natl. Acad. Sci. USA 110 12283
2) Pletzer et al. (2015), The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol. 197 2217
3) Asada et al. (2015), Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One, 10 e0125993
4) Garg and Qadri (2010), Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol. 184 5980

Focus Biomolecules supplier, chemical structure Blasticidin S HCl | Antibiotic selection agent | CAS 3515-03-9

Catalog#  10-2830-0020

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Catalog Number:
Blasticidin S HCl
Chemical Name:
(S)-4-[[3-Amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-hex-2-enopyranuronic acid hydrochloride
Molecular Weight:
Molecular Formula:
C17H26N8O5 &bul; HCl
Soluble in Water (greater than 25 mg/ml)
Physical Properties:
White solid
99% by HPLC
NMR (Conforms)
Storage Temperature:
-20°C (des.)
Stable for 1 year as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Shipping Code:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications.

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