Amphotericin B | Antifungal agent
NMR (Conforms)
Available Options
| Size: | Price | Quantity | |
|---|---|---|---|
| 1 g | $60.00 | ||
| 5 g | $240.00 |
Amphotericin B (1397-89-3) is a powerful antimycotic, effective against a wide variety of fungi, including yeast, via two mechanisms: forming pores in the plasma membrane, leading to leakage and death1, and causing oxidative stress2. Other mechanisms have more recently been proposed, including formation of intracellular amphotericin B-containing vesicular bodies that target vacuoles.3 Amphotericin B is also effective against some parasites, such as Leishmania spp.4 Because of its potency and broad-spectrum activity, it is a common additive used to maintain sterility in cell culture and viral transport media.
References:
- Kinsky et al. (1970), Antibiotic interaction with model membranes; Annu. Rev. Pharmacol., 10 119
- Sokol-Anderson et al. (1986), Amphotericin B-Induced Oxidative Damage and Killing of Candida Albicans; Infect. Dis., 154 75
- Grela et al. (2019), Modes of the antibiotic activity of amphotericin B against Candida albicans; Rep., 9 17029
- Paila et al. (2010), Amphotericin B inhibits entry of Leishmaniz donovani into primary macrophages; Biophys. Res. Commun., 399 429
NMR (Conforms)
Safety Data Sheet:
Product Data Sheet:
Materials provided by Focus Biomolecules are for laboratory research use only and are not intended for human or veterinary applications. Please note that we do not sell to individuals and that all orders placed by non-research organizations will incur a $20 restocking/refund fee
Amphotericin B (1397-89-3) is a powerful antimycotic, effective against a wide variety of fungi, including yeast, via two mechanisms: forming pores in the plasma membrane, leading to leakage and death1, and causing oxidative stress2. Other mechanisms have more recently been proposed, including formation of intracellular amphotericin B-containing vesicular bodies that target vacuoles.3 Amphotericin B is also effective against some parasites, such as Leishmania spp.4 Because of its potency and broad-spectrum activity, it is a common additive used to maintain sterility in cell culture and viral transport media.
References:
- Kinsky et al. (1970), Antibiotic interaction with model membranes; Annu. Rev. Pharmacol., 10 119
- Sokol-Anderson et al. (1986), Amphotericin B-Induced Oxidative Damage and Killing of Candida Albicans; Infect. Dis., 154 75
- Grela et al. (2019), Modes of the antibiotic activity of amphotericin B against Candida albicans; Rep., 9 17029
- Paila et al. (2010), Amphotericin B inhibits entry of Leishmaniz donovani into primary macrophages; Biophys. Res. Commun., 399 429
Related products
-
SAHA | HDAC inhibitor
From $35.00CAS:149647-78-9Catalog Number:10-1067Activity:HDAC inhibitorAlternate Names:VorinostatChemical Name:Suberoylanilide-hydroxamic acidMolecular Weight:264.33Molecular Formula:C14H20N2O3Solubility:Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 2 mg/ml).Physical Properties:White solidPurity:98%
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 6 months.Shipping Code:RT -
Nafamostat Mesylate | Serine protease inhibitor
From $50.00CAS:82956-11-4Catalog Number:10-1089Activity:Serine protease inhibitorAlternate Names:Futhan; FUT-175Chemical Name:6-Amidino-2-naphthyl-4-guanidinobenzoate dimesylateMolecular Weight:539.59Molecular Formula:C19H17N5O2·2CH4O3SSolubility:Soluble in Water (up to 25 mg/ml).Physical Properties:White solidPurity:98% by TLC
NMR (Conforms)Storage Temperature:RTStability:Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at 4°C for up to 1 month, or at -80°C for up to 6 months.Shipping Code:RT -
Mifepristone | Glucocorticoid antagonist
From $50.00CAS:84371-65-3Catalog Number:10-1053Activity:Glucocorticoid antagonistAlternate Names:RU486Chemical Name:11β-[4-(Dimethylamino)phenyl]-17β-hydroxy-17-(1-propynyl)estra-4,9-dien-3-oneMolecular Weight:429.59Molecular Formula:C29H35NO2Solubility:Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 20 mg/ml).Physical Properties:Yellow solidPurity:>98% by TLCStorage Temperature:RTStability:Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.Shipping Code:RT
Calculate the molar concentration, mass or volume in a solution.
Concentration × Volume × Molecular Weight = Mass
Focus Biomolecules • Plymouth Meeting, PA USA • 1-855-FOCUS21
Focus Biomolecules
Plymouth Meeting, PA USA
1-855-FOCUS21
Website Created by Advanta Advertising LLC.